Synthesis and antimicrobial properties of new copper (II) complexes with benzoate of ethyl 4-({2-[(pyridin-2-yl) methylidene] hydrazinecarbothioyl} amino)
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2019-11-25 09:18
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RUSNAC, Anna; BALAN, Greta; TSAPKOV, Viktor; GULEA, Aurelian. Synthesis and antimicrobial properties of new copper (II) complexes with benzoate of ethyl 4-({2-[(pyridin-2-yl) methylidene] hydrazinecarbothioyl} amino). In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 140. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

Synthesis and antimicrobial properties of new copper (II) complexes with benzoate of ethyl 4-({2-[(pyridin-2-yl) methylidene] hydrazinecarbothioyl} amino)


Pag. 140-140

Rusnac Anna1, Balan Greta2, Tsapkov Viktor1, Gulea Aurelian1
 
1 State University of Moldova,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 7 noiembrie 2019


Rezumat

Throughout history, it has been a major worldwide problem to treat microbial diseases caused by bacteria due to the impetuous development of resistance to antibacterial drugs. Thiosemicarbazones have been investigated for medicinal studies for a long while due to their wide range of biological activities including antineoplastic, antimycobacterial, antibacterial, antifungal, antiviral, and antimalarial effects. We have synthesized the new thiosemicarbazone(5). Ethyl 4-[(hydrazinecarbothioyl)amino]benzoate (4) was obtained according to the following steps. First step: Ethyl 4aminobenzoate (1) reacted with tetramethylthiuram disulfide (TMTD) in a molar ratio 1:1 upon heating in dimethylformamide to form ethyl 4-[(dimethylcarbamothioyl)amino]-benzoate (2). In the second step, compound (2) was decomposedin 1,4-dioxaneabsolute with sulphuric acid to form ethyl 4-isothiocyanatobenzoate (3). Compound (4) was obtained by dropping isothiocyanate(3) to a solution of hydrazine hydrate in ethanol.Benzoate of ethyl 4-({(2[(pyridin-2-yl)methylidene]hydrazinecarbothioyl}amino)(5) (HL) was obtained from the reaction between compound 4 and formylpyridine in ethanol. The reaction mixture was refluxed for 6 h. Its purity was confirmed by thin layer chromatography, spectroscopy (1H, 13C-NMR and FTIR). Scheme of synthesis ofHL.Complexes were synthesisedas is derived here: to a hot solution of HL in ethanol were added corresponding copper salts in proportion 1:1. The mixture was heated at reflux for 1 h. Complexes precipitated as dark green crystalline solid, and collected by filtration, washed thoroughly with ethanol and then dried in air. The obtained complexes were analyzed by using FTIR spectroscopy and metal analysis. Five copper complexes (II) have been tested on antimicrobial activity. The best results were recorded ongram-positive bacteria Staphylococcus aureus by CuLCl.