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SM ISO690:2012 DUCEACA, Ioana Alexandra, TANASA, Fulga. CHITOSAN – a versatile platform for biomedical applications. I. CHITOSAN-based media for controlled delivery of bioactive compounds. In: Achievements and perspectives of modern chemistry, 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 61. ISBN 978-9975-62-428-2. |
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Achievements and perspectives of modern chemistry 2019 | ||||||
Conferința "International Conference "Achievements and perspectives of modern chemistry"" Chişinău, Moldova, 9-11 octombrie 2019 | ||||||
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Pag. 61-61 | ||||||
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Chitosan, one of the most widely used natural polysaccharides, has been considered for biomedical applications due to its excellent biocompatibility, low toxicity, immune-stimulatory action and tissue repair capability. Aside these characteristics, there are other properties that influence its use as support for the delivery of various compounds with biologic activity (i.e., growth factors, drugs, nucleic acids) [1]. Thus, the molecular weight and degree of acetylation affect its solubility and its hydrophobic character, as it is insoluble in most organic solvents, but highly soluble in water under acidic conditions due to the protonation of the amine groups. Its susceptibility to degradation by lysozyme and chitinase, its mucoadhesive nature and the ability to temporarily open some epithelial tight junctions favour the delivery of drugs across well-organized epithelia (such as nasal, intestinal, ocular, buccal and lung). At the same time, the presence of the reactive functional groups on the macromolecular chain allows the chemical binding of drug molecules [2]. All these features make chitosan a highly convertible platform for such applications. Therefore, it is intensively studied and used in controlled delivery of bioactive compounds, whether it is employed as films, nano-/micro- capsules or particles, hydrogels, coatings or even as matrix to assembly bio(macro)molecules, cells, nanoparticles, etc. by chemical and/or physical bonds [3], as it will be presented herein. |
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