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SM ISO690:2012 OLAR, Rodica, BADEA, Mihaela, CALU, Larisa, CELAN KOROSIN, Natasa, DAVID, Iulia, CHIFIRIUC, Mariana-Carmen, MĂRUŢESCU, Luminiţa. Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 481. ISBN 978-3-940237-47-7. |
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Central and Eastern European Conference on Thermal Analysis and Calorimetry Editia 4, 2017 |
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Conferința "Central and Eastern European Conference" 4, Chişinău, Moldova, 28-31 august 2017 | |||||
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Pag. 481-481 | |||||
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Triazolopyrimidines similarity with DNA purine nucleobases generated development of derivatives with a large spectrum of biological effects such as analgesic, anti-inflammatory, antimicrobial, antiviral, antitumor and cardiovascular [1]. Furthermore, complexes with such ligands were studied from point of view of antimicrobial, antitumor or antiparasitic activity [2] as well as thermal behavior [3]. In order to modulate biological activity new species of type M(pmtp)(ClO4)2⋅nH2O (M: Co, Ni, Cu, Zn; pmtp: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesised and characterised by chemical analysis, ESI-MS, IR, UV-Vis-NIR, EPR spectroscopy, cyclic voltammetry and magnetic data at room temperature. The in vitro screening of the antimicrobial activity were performed against Gram positive (S. aureus, B. subtilis), Gram negative (E. coli, K. pneumoniae, P. aeruginosa), both reference and clinical multidrug resistant strains. Zinc(II) complex was the most active, with minimum inhibitory concentration (MIC) in the range 31-125 μg mL-1. Instead, all complexes have the ability to inhibit the biofilm adhesion on inert substratum. In order to evidence the modifications at heating and also the thermodynamics effects that accompany them the thermal behaviour of these derivatives was investigated by simultaneous TG/DSC/MS measurements. Processes as water elimination, perchlorate decomposition, fragmentation and oxidative degradation of the triazolopyrimidine species were observed during the thermal studies. |
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