Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative
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OLAR, Rodica, BADEA, Mihaela, CALU, Larisa, CELAN KOROSIN, Natasa, DAVID, Iulia, CHIFIRIUC, Mariana-Carmen, MĂRUŢESCU, Luminiţa. Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 481. ISBN 978-3-940237-47-7.
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Central and Eastern European Conference on Thermal Analysis and Calorimetry
Editia 4, 2017
Conferința "Central and Eastern European Conference"
4, Chişinău, Moldova, 28-31 august 2017

Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative


Pag. 481-481

Olar Rodica12, Badea Mihaela12, Calu Larisa1, Celan Korosin Natasa3, David Iulia1, Chifiriuc Mariana-Carmen1, Măruţescu Luminiţa1
 
1 University of Bucharest,
2 Central and Eastern European Committee for Thermal Analysis and Calorimetry,
3 University of Ljubljana
 
Disponibil în IBN: 30 octombrie 2019


Rezumat

Triazolopyrimidines similarity with DNA purine nucleobases generated development of derivatives with a large spectrum of biological effects such as analgesic, anti-inflammatory, antimicrobial, antiviral, antitumor and cardiovascular [1]. Furthermore, complexes with such ligands were studied from point of view of antimicrobial, antitumor or antiparasitic activity [2] as well as thermal behavior [3]. In order to modulate biological activity new species of type M(pmtp)(ClO4)2⋅nH2O (M: Co, Ni, Cu, Zn; pmtp: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesised and characterised by chemical analysis, ESI-MS, IR, UV-Vis-NIR, EPR spectroscopy, cyclic voltammetry and magnetic data at room temperature. The in vitro screening of the antimicrobial activity were performed against Gram positive (S. aureus, B. subtilis), Gram negative (E. coli, K. pneumoniae, P. aeruginosa), both reference and clinical multidrug resistant strains. Zinc(II) complex was the most active, with minimum inhibitory concentration (MIC) in the range 31-125 μg mL-1. Instead, all complexes have the ability to inhibit the biofilm adhesion on inert substratum. In order to evidence the modifications at heating and also the thermodynamics effects that accompany them the thermal behaviour of these derivatives was investigated by simultaneous TG/DSC/MS measurements. Processes as water elimination, perchlorate decomposition, fragmentation and oxidative degradation of the triazolopyrimidine species were observed during the thermal studies.