Terpenenoids from the Hainan soft corals: structure, absolute stereochemistry and biological activities
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2020-10-13 10:34
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GUO, Yuewei. Terpenenoids from the Hainan soft corals: structure, absolute stereochemistry and biological activities. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 24. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

Terpenenoids from the Hainan soft corals: structure, absolute stereochemistry and biological activities


Pag. 24-24

Guo Yuewei
 
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
 
Disponibil în IBN: 30 octombrie 2019


Rezumat

Soft corals are marine benthic invertebrates widely distributed in the coral reefs of the world oceans. Of them, the animals belonging to the genera Sarcophyton, Lobophytum, Sinularia (phylum Cnidaria, class Anthozoa, subclass Octocorallia, order Alcyonaceae, family Alcyoniidae) are very prolific and are the intense research subjects for marine natural product chemists. Literature checking revealed that these Cnidaria animals can produce different structural classes of secondary metabolites exhibiting various interesting biological activities ranging from antifouling, anti-inflammatory to cytotoxic activities. Among the metabolites reported, cembrane-type diterpenes are the most frequently encountered. Recently, quite a lot of cembrane-derived metabolites possessing rare and/or unprecedented frameworks were reported. Moreover, biscembranoids, characterized by the complex and highly oxygeneted macrocyclic frameworks, which are formally synthesized from two different cembranoid units via a probable [4+2] Diels-Alder cyclic addition, are unique and typical natural products from soft corals of the genus Sarcophyton. Due to the flexible nature of the macrocyclic cembranoids accompanying with the highly diverse substitution patterns, it has been being a challenging task for their structural determination, in particular, the absolute stereochemistry by natural product chemists. In this presentation, the latest chemical studies and promising bioactivity of some isolates from the corals of above mentioned three genera collected from South China Sea will be reported. All work has been performed in close collaboration with marine biologists and with pharmacologists.