Rivastigmine, a parasympathomimetic and reversible cholinesterase inhibitor, is used to treat mild to moderate dementia associated with Parkinson's or Alzheimer’s disease [1]. Considering the low risk of the exhibited side effects, nausea and vomiting, research is focused on obtaining a complete physico-chemical profile in order to develop new pharmaceutical formulations that increase therapeutic compliance [2]. a b Thermoanalytical curves TG/DTG/HF (a) and UATR spectrum (b) of rivastigmine The present study describes the investigation of thermal degradation process in a dynamic air atmosphere at five different heating rates, up to 500 °C. In order to evaluate the values of the activation energies, three isoconversional methods were utilized (Kissinger–Akahira–Sunose, Flynn-Wall-Ozawa and Friedman), the different processes that occur during thermal treatment being afterwards analysed following the NPK method [3].