The approach starts from the analysis of the evolution of some important indicators that characterize the socio-economic situation of today in the Republic of Moldova and which certainly affect the possibility of socio-professional inclusion of people with disabilities. The pressure of demographic changes occurring at European level also has repercussions on the Republic of Moldova, registering a slow and continuous process of decreasing population numbers. The factors that have determined this phenomenon are: the decrease of the birth rate and the increase of the aging coefficient of the population. The employment rate of people with disabilities in the Republic of Moldova has low values. The main factors that contribute to maintaining high values for the unemployment rate among people with disabilities are:  the low level of education and training at the time of transition to the labor market, the mismatch between their qualifications and the skills required by employers, the still low impact of apprenticeship schemes and of professional traineeships, limited supply of jobs for people with special needs. One of the basic objectives of the National Strategy on Employment for the period 2017-2021, approved by the Gov. decision no. 1473 of December 30, 2016 (SNOFM 2017-2021) is: “Creating formal, non-discriminatory and productive employment opportunities”. Ensuring an active entrepreneurial ecosystem is one of the best ways to tackle the problem of unemployment among people with disabilities. By supporting the creation and development of entrepreneurial initiatives, more jobs will be created, including jobs linked to the organic comfort of the beneficiary. Secondly, young people themselves can become entrepreneurs and develop their own businesses. In order to reduce unemployment among people with disabilities, and especially young people, it is necessary to develop an instrument that would have the mission of guaranteeing inclusion. It is necessary that this instrument combines key reforms and initiatives aimed at creating the appropriate framework for the employment of people with disabilities if they have previously experienced failure in previous employment. Through the prism of this instrument it is possible to analyze the individual (or group) socio-professional inclusion needs, in order to offer the possibility of a second chance.