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SM ISO690:2012 ZARAFU, Irina, OLAR, Rodica, BADEA, Mihaela, CHIFIRIUC, Mariana-Carmen, BUCUR, Marcela, IONIŢĂ, Petre, PĂUN, Anca, MULŢESCU, Mihaela, IONIŢĂ, Gabriela. Insight on thermal, spectral and antimicrobial profile of Cu(II) complexes with Schiff base ligands. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 462. ISBN 978-3-940237-47-7. |
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Central and Eastern European Conference on Thermal Analysis and Calorimetry Editia 4, 2017 |
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Conferința "Central and Eastern European Conference" 4, Chişinău, Moldova, 28-31 august 2017 | |
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Pag. 462-462 | |
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Copper(II) species are usually used for obtaining complexes with a large spectrum of biological activity based on its stereochemical diversity and ability to generate redox reactions. On the other hand, multidentate hydrazones generate both stable complexes and modulate biological activity of complexes. Several studies evidenced an enhanced antitumor, antiviral or antimicrobial activity for Cu(II) complexes with nitrogen-chelating ligands [1]. Some of these species were studied also concerning thermal behaviour [2]. In order to develop new metallo-antimicrobials a series of complexes of type CuL(CH3COO)·nH2O (L: Schiff bases resulted in [1+1] condensation of 8-alkyle-2-hydroxytriciclo[ 7.3.1.02.7]-trideca-13-one and 4-amino-1-phenyle-2,3-dimethyle-pyrazolone were synthesized. The ligands and complexes features have been assigned from microanalytical, ESI-MS, IR, UV-Vis-NIR and EPR data. All these investigations account for a square-pyramidal or an octahedral stereochemistry. The in vitro screening of the antimicrobial activity performed against Gram positive (S. aureus, B. subtilis), Gram negative (P. aeruginosa, E. coli, Enterobacter spp.) and C. albicans reference strains indicates an overall good activity for all complexes. Complexes display a similar thermal behaviour. Processes as water endothermic elimination as well as oxidative degradation of both acetate and Schiff bases were evidenced according with TG and DTA curves profile. |
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