Insight on thermal, spectral and antimicrobial profile of Cu(II) complexes with Schiff base ligands
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2024-01-18 13:53
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ZARAFU, Irina, OLAR, Rodica, BADEA, Mihaela, CHIFIRIUC, Mariana-Carmen, BUCUR, Marcela, IONIŢĂ, Petre, PĂUN, Anca, MULŢESCU, Mihaela, IONIŢĂ, Gabriela. Insight on thermal, spectral and antimicrobial profile of Cu(II) complexes with Schiff base ligands. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 462. ISBN 978-3-940237-47-7.
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Central and Eastern European Conference on Thermal Analysis and Calorimetry
Editia 4, 2017
Conferința "Central and Eastern European Conference"
4, Chişinău, Moldova, 28-31 august 2017

Insight on thermal, spectral and antimicrobial profile of Cu(II) complexes with Schiff base ligands


Pag. 462-462

Zarafu Irina1, Olar Rodica12, Badea Mihaela12, Chifiriuc Mariana-Carmen1, Bucur Marcela1, Ioniţă Petre1, Păun Anca1, Mulţescu Mihaela1, Ioniţă Gabriela3
 
1 University of Bucharest,
2 Central and Eastern European Committee for Thermal Analysis and Calorimetry,
3 “Ilie Murgulescu” Institute of Physical Chemistry of the Romanian Academy
 
Disponibil în IBN: 28 octombrie 2019


Rezumat

Copper(II) species are usually used for obtaining complexes with a large spectrum of biological activity based on its stereochemical diversity and ability to generate redox reactions. On the other hand, multidentate hydrazones generate both stable complexes and modulate biological activity of complexes. Several studies evidenced an enhanced antitumor, antiviral or antimicrobial activity for Cu(II) complexes with nitrogen-chelating ligands [1]. Some of these species were studied also concerning thermal behaviour [2]. In order to develop new metallo-antimicrobials a series of complexes of type CuL(CH3COO)·nH2O (L: Schiff bases resulted in [1+1] condensation of 8-alkyle-2-hydroxytriciclo[ 7.3.1.02.7]-trideca-13-one and 4-amino-1-phenyle-2,3-dimethyle-pyrazolone were synthesized. The ligands and complexes features have been assigned from microanalytical, ESI-MS, IR, UV-Vis-NIR and EPR data. All these investigations account for a square-pyramidal or an octahedral stereochemistry. The in vitro screening of the antimicrobial activity performed against Gram positive (S. aureus, B. subtilis), Gram negative (P. aeruginosa, E. coli, Enterobacter spp.) and C. albicans reference strains indicates an overall good activity for all complexes. Complexes display a similar thermal behaviour. Processes as water endothermic elimination as well as oxidative degradation of both acetate and Schiff bases were evidenced according with TG and DTA curves profile.