An international perspective on hospitalized patients with viral community-acquired pneumonia
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RADOVANOVIC, Dejan, BROCOVSCHII, Victoria, CHESOV, Ion, NOI, Autori, RUSU, Doina, TOMA, Cristina. An international perspective on hospitalized patients with viral community-acquired pneumonia. In: European Journal of Internal Medicine, 2019, nr. 60, pp. 54-70. ISSN 0953-6205. DOI: https://doi.org/10.1016/j.ejim.2018.10.020
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European Journal of Internal Medicine
Numărul 60 / 2019 / ISSN 0953-6205

An international perspective on hospitalized patients with viral 

community-acquired pneumonia

DOI: https://doi.org/10.1016/j.ejim.2018.10.020

Pag. 54-70

Radovanovic Dejan1, Brocovschii Victoria2, Chesov Ion2, Noi Autori, Rusu Doina2, Toma Cristina2
 
1 University of Milan,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 9 octombrie 2019


Rezumat

Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor. 

Cuvinte-cheie
community acquired pneumonia, influenza, Oseltamivir, testing, Viral pneumonia, Viral swab