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 SM ISO690:2012CORLAN, Ana Silvia, CIMPEAN, Anca-Maria, MELNIC, Eugen, RAICA, Marius, SÂRB, Simona. VEGF, VEGF165b and EG-VEGF: Expression is specifically related with hormone profile in pituitary adenomas. In: European Journal of Histochemistry, 2019, nr. 1(63), pp. 47-52. ISSN 1121-760X. DOI: https://doi.org/10.4081/ejh.2019.3010 |
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 European Journal of Histochemistry |
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| Numărul 1(63) / 2019 / ISSN 1121-760X | ||||||
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| DOI:https://doi.org/10.4081/ejh.2019.3010 | ||||||
| Pag. 47-52 | ||||||
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Vascular endothelial growth factor (VEGF), its inhibitory splice variant, VEGF165b and Endocrine Gland derived VEGF (EG-VEGF) have a controversial role in pituitary gland. We aim to study VEGF, VEGF165b and EG-VEGF expression in pituitary adenomas. A significant correlation was found between growth hormone (GH) and VEGF secretion (P=0.024). For prolactinomas, VEGF and prolactin expression, had a P-value of 0.02 for Kendall coefficient and a P-value of 0.043 for the Spearman coefficient. VEGFmRNA amplification was detected in both tumor cells and folliculostellate cells. VEGF165b was positive in 16.66% of pituitary adenomas. EG-VEGF was significantly correlated with prolactin (P=0.025) and luteinizing hormone (P=0.028). Our data strongly support VEGF, VEGF165b and EG-VEGF as important players of pituitary adenomas tumorigenesis. Particular hormonal milieu heterogeneity, special vascular network with an unusual reactivity to tumor growth correlated with variability of VEGF, VEGF165b and EG-VEGF secretion may stratify pituitary adenomas in several molecular groups with a direct impact on therapy and prognosis. |
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| Cuvinte-cheie angiogenesis, EG-VEGF, Pituitary adenomas, VEGF VEGF165b |
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