Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents
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DUCA, Gheorghe; ARICU, Aculina; KUCHKOVA, Kaleria; SECARA, Elena; BARBĂ, Alic; DRAGALIN, Ion; UNGUR, Nicon; SPENGLER, Gabriella. Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents. In: Natural Product Research. 2019, nr. 21(33), pp. 3052-3056. ISSN 1478-6419.
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Natural Product Research
Numărul 21(33) / 2019 / ISSN 1478-6419 /ISSNe 1478-6427

Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents

DOI: 10.1080/14786419.2018.1516658
Pag. 3052-3056

Duca Gheorghe1, Aricu Aculina1, Kuchkova Kaleria1, Secara Elena1, Barbă Alic1, Dragalin Ion1, Ungur Nicon1, Spengler Gabriella2
1 Institute of Chemistry,
2 University of Szeged
Disponibil în IBN: 6 octombrie 2019


Using sclareol and sclareolide as starting materials, the guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-bis-dinorlabd-8(9)-ene were synthesized by the reaction of the corresponding amines with sodium hydrogencyanamide in ethanol–water solution. Monoacyl- and diacylguanidines were prepared from activated with N,N-carbonyldiimidazole Δ8,9-bicyclohomofarnesenoic acid by the reaction with guanidine. Their structures were confirmed by the 1H and 13C NMR, IR spectral and elemental analysis data. The compounds 12, 13 and 15 were screened for their antiproliferative and cytotoxicity activities against Colo 205, Colo 320 and MRC 5 human lung fibroblasts with respect to standard drug, Cisplatin. The compounds 12 and 15 exhibits excellent results than positive control. Hence these two compounds may be act as drug lead molecules in cancer chemotherapy.

14, 15-Bis-norlabdane, antiproliferative activity, dihomodrimane, Guanidines, synthesis, terpenoids

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author = {Pleşca, E.V.},
title = {<p><span style="font-family:&quot;Calibri&quot;,sans-serif; font-size:12.0pt; line-height:107%; mso-ansi-language:EN-US; mso-ascii-theme-font:minor-latin; mso-bidi-font-family:&quot;Times New Roman&quot;; mso-bidi-language:AR-SA; mso-bidi-theme-font:minor-bidi; mso-fareast-font-family:Calibri; mso-fareast-language:EN-US; mso-fareast-theme-font:minor-latin; mso-hansi-theme-font:minor-latin">Cuvinte cu etimologie necunoscută &icirc;n limba rom&acirc;nă</span></p>},
collection = {Lecturi in memoriam acad. Silviu Berejan},
year = {2020},
volume = {Vol. 4},
pages = {80-87},
abstract = {(RO) <p>&Icirc;n comunicare sunt abordate aspecte legate de cuvintele cu etimologie necunoscută &icirc;n limba rom&acirc;nă (după DLR). &Icirc;n majoritatea lor, acestea sunt cuvinte din vorbirea populară şi regionalisme. Autoarea prezintă soluţii şi sugestii etimologice pentru cuvintele cu etimologie necunoscută &oacute;tuv adj., &oacute;tova adj., ot&aacute;ştină sb., otoboc sb., odob&acirc;ncă sb., năv&acirc;lcă sb., năzgovenie sb., care, după toate probabilităţile, pot fi apreciate ca &icirc;mprumuturi slave. &nbsp;</p>},
abstract = {(EN) <p>The communication addresses issues related to the words with unknown etymology in Romanian language (after DLR (Romanian language dictionary)). In most of these are words from people&rsquo;s speech and regionalism. The author presents etymological solutions and suggestions for words with unknown etymology: otuv-adjective, &oacute;tovaadjective, otaștină-noun, otoboc-noun, odob&acirc;ncă-noun, năv&acirc;lcă-noun, năzgovenie-noun, in all probability, these words can be assessed as slave borrowings. &nbsp;</p>},
url = {},
keywords = {statistică, etimologie necunoscută, etimologie nesigură, împrumut, aspect fonetic, semantică, Statistics, words with unknown etymology, borrowing, phonetic and semantic change, imperfective aspect}