Thermal analysis and kinetic study of deprenyl hydrochloride
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LEDEŢI, Adriana, CIRCIOBAN, Denisa, VLASE, Gabriela, CAUNII, Angelica, ŞUTA, Lenuţa-Maria, VLASE, Titus, LEDEŢI, Ionuţ. Thermal analysis and kinetic study of deprenyl hydrochloride. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 230. ISBN 978-3-940237-47-7.
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Central and Eastern European Conference on Thermal Analysis and Calorimetry
Editia 4, 2017
Conferința "Central and Eastern European Conference"
4, Chişinău, Moldova, 28-31 august 2017

Thermal analysis and kinetic study of deprenyl hydrochloride


Pag. 230-230

Ledeţi Adriana1, Circioban Denisa1, Vlase Gabriela1, Caunii Angelica1, Şuta Lenuţa-Maria1, Vlase Titus2, Ledeţi Ionuţ1
 
1 Victor Babes University of Medicine and Pharmacy, Timişoara,
2 West University of Timisoara
 
Disponibil în IBN: 30 septembrie 2019


Rezumat

Deprenyl hydrochloride, or more commonly known as selegiline, is used in the first stages of Parkinson's disease as monotherapy or in combination with L-Dopa in more advanced stages, but also in major depressive disorder [1]. Due to its low oral bioavailability, new formulations are studied in order to improve this disadvantage and a comprehensive behaviour study is of the utmost importance [2]. a b Thermoanalytical curves TG/DTG/HF (a) and UATR spectrum (b) of deprenyl hydrochloride The thermoanalytical studies for selegiline were performed using five heating rates β=5, 7, 10, 12 and 15 °C min-1 and the obtained data was analysed using the Kissinger–Akahira–Sunose, Flynn-Wall-Ozawa and Friedman isoconversional methods in order to determine the apparent values for the activation energies. Considering that the thermal degradation behaviour of the analysed compound could have had chemical or physical background, the results of the performed tests were interpreted using the NPK method, for the precise identification of each type of process [3]. The chosen analytical methods were an important tool used in the determination of the kinetic parameters that characterize the specific profile of deprenyl hydrochloride.