Sol-gel synthesis and chemical, structural and thermal characterization of inorganic/organic hybrid materials for biomedical applications

Catauro Michelina; Tuffi Riccardo; Vecchio Ciprioti Stefano

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CATAURO, Michelina, TUFFI, Riccardo, VECCHIO CIPRIOTI, Stefano. Sol-gel synthesis and chemical, structural and thermal characterization of inorganic/organic hybrid materials for biomedical applications. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 152. ISBN 978-3-940237-47-7.

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Central and Eastern European Conference on Thermal Analysis and Calorimetry
Editia 4, 2017

Conferința "Central and Eastern European Conference"
4, Chişinău, Moldova, 28-31 august 2017

Sol-gel synthesis and chemical, structural and thermal characterization of inorganic/organic hybrid materials for biomedical applications

Pag. 152-152

Catauro Michelina¹, Tuffi Riccardo², Vecchio Ciprioti Stefano³

¹ University of Campania “Luigi Vanvitelli”,
² ENEA - Casaccia Research Centre,
³ Sapienza University of Rome

Disponibil în IBN: 29 august 2019

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The study of organic-inorganic nanocomposites networks for biomedical applications has recently become an expanding field of investigation [1]. Sol-gel process has proved to be versatile and has been widely used in the preparation of organic/inorganic hybrid biomaterials [3], non-linear optical and mesoporous materials [4, 5]. The sol-gel chemistry is based on the hydrolysis and polycondensation of metal alkoxides M(OR)x, where M = Si, Sn, Zr, Ti, Al, Mo, V, W, Ce and so forth. SiO2/PEG and ZrO2/PEG organic-inorganic hybrid materials, which differ in polyethylene glycol (PEG) content, were synthesized by the sol-gel technique, and their structural characterization, the study of the thermal behavior and biological properties were carried out in order to evaluate their possible use in biomedical field. FT-IR spectroscopy revealed that the inorganic (SiO2 or ZrO2) and the organic (PEG) components of the hybrids are linked by hydrogen bonds between the Si-OH or Zr-OH groups of the inorganic phase and the terminal alcoholic groups and/or the ethereal oxygen atoms in the repeating units of the polymer. X-ray diffraction analysis ascertained the amorphous nature of the gels, while the observation of their morphology by SEM microscopy confirmed that the interpenetration of the two phases (organic and inorganic) occurs on a nanometric scale. In order to evaluate the possible use of these materials for biomedical applications their bioactivity and biocompatibility were tested. All SiO2/PEG and ZrO2/PEG organic-inorganic hybrid materials were found to be bioactive and biocompatible, regardless the polymer amount. The thermal behavior of all the hybrid materials was studied for the first time by Thermogravimetry (TG) and Differential Thermal Analysis (DTA), aiming at identifying all physical and chemical processes occurring in these interesting materials, with particular reference to the decomposition of PEG. Their thermal stabilities and the most suitable temperature condition for a further thermal treatment were also determined.

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