Purpose: study the systemic interaction of the brain and the heart during the information processing in athletes with different individual and typological properties of the higher parts of the central nervous system. Material: In 83 athletes while mental working were simultaneously registered: 1) electroencephalogram (EEG), central hemodynamics and heart rate variability (HRV); 2) cerebral hemodynamics and HRV; 3) EEG, HRV and electrical resistance of the skin. Individual and typological features of CNS were determined by functional mobility, strength, and equilibrium of the nervous processes. Results: It is revealed that brain-heart systemic interaction is organized in the form of a few clusters and has individual and typological features in athletes. The analysis of indicators of neurophysiological and vegetative functions of the surveyed persons indicates that during the processing of information, the interaction of the brain and the cardiovascular system of human was determined by the level of individual and typological properties of the higher parts of the CNS. This is manifested in athletes also during physical load. Conclusions: Brain-heart systemic interaction is caused by individual-typological properties of central nervous system. It is important for sport orientation, clinical prognosis of cardiovascular and neurological deviations, and optimization of rehabilitation measures.