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Ultima descărcare din IBN: 2023-10-13 12:02 |
SM ISO690:2012 ARORA, Silki, PARK, Sang Hoon, MAUSER , Jennifer, CHAKRABARTI, Debopam, SCHULTE, Alfons. Micro-spectroscopy of single erythrocytes infected with the Malaria Parasite. In: Nanotechnologies and Biomedical Engineering, Ed. 1, 7-8 iulie 2011, Chișinău. Technical University of Moldova, 2011, Editia 1, pp. 252-254. ISBN 978-9975-66-239-0.. |
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Nanotechnologies and Biomedical Engineering Editia 1, 2011 |
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Conferința "International Conference on Nanotechnologies and Biomedical Engineering" 1, Chișinău, Moldova, 7-8 iulie 2011 | |
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Pag. 252-254 | |
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The erythrocytic cycle of the malaria parasite Plasmodium falciparum is marked with structural, mechanical and biochemical modifications to the host red blood cell. The parasite degrades the hemoglobin of the host cell and hydrolyzes it into hemozoin. We investigate healthy and infected erythrocytes using microRaman and spatially resolved absorption spectroscopy. The electronic absorption spectrum of a single cell is measured and spectral changes are related to the parasite life cycle. The Soret absorption band in the trophozoite stage is shifted to higher wavelength by 3 nm. The findings are compared with micro-Raman spectra that show consistent changes in the heme vibrations. Micro-absorption may offer a potential diagnostic marker for identifying pathological states accompanying malaria. |
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Cuvinte-cheie Absorption microscopy, diagnostics, erythrocyte, malaria parasite, Raman spectroscopy |
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