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Articolul precedent |
Articolul urmator |
873 23 |
Ultima descărcare din IBN: 2023-04-10 17:33 |
Căutarea după subiecte similare conform CZU |
616.13/.14-002.7:616.33-053.2 (1) |
Patologia sistemului circulator, a vaselor sanguine. Tulburări cardiovasculare (975) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1732) |
SM ISO690:2012 REVENCO, Ninel, EREMCIUC, Rodica, GAIDARJI, Olga, FOCA, Silvia-Gabriela, BOTNARU, Victor, GUDUMAC, Eva, CRIVCEANSCHI, Eugenia, MARIN, Ala, TIRON, Ludmila, PETROVICI, Virgil. Interrelațiile dintre granulomatoza cu poliangeită, portajul stafilococului auriu și infecțiile acute – caz clinic. In: Buletin de Perinatologie, 2019, nr. 2(83), pp. 112-116. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(83) / 2019 / ISSN 1810-5289 | ||||||
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CZU: 616.13/.14-002.7:616.33-053.2 | ||||||
Pag. 112-116 | ||||||
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Background: Granulomatosis with polyangiitis (GPA) is a chronic vasculitis involving small- to medium-sized arteries. It is characterized by granulomatous infl ammation of the upper and lower respiratory tracts; necrotizing, pauci-immune glomerulonephritis; and vasculitis that frequently involves other organs. Staphylococcus aureus is thought to play a crucial role in onset and fl ares of GPA. Method and materials: We report a clinical case of a patient with granulomatosis with polyangiitis complicated with infective endocarditis due to Staph. aureus. Results: At the onset of the disease patient complaint on persistent fever, anorexia, nausea and vomiting. Laboratory assays revealed increased acute phase reactants. X-ray revealed signs of sinusitis and pulmonary infection. Septic workup revealed repeated positive blood cultures for staph. aureus. In spite to adequate antibiotic treatment child’s condition gradually worsened. Nasal crusting and epistaxis was reported by patient. An repeated X-ray of the chest showed multiple nodules and cavities in the lungs. She was suspected to have GPA. Lung biopsy was taken and the diagnosis of GPA was confi rmed. Imunnosupresive therapy was started with no expected clinical improvement. In the meanwhile patient developed a new murmur. On heart ultrasound vegetations were revealed. Th e diagnosis of infective endocarditis was made. Th e patient was treated with a 4 weeks regimen of vancomycin. Her condition markedly improved. Aft er the treatment of active infection, an alternative regimen of GPA treatment was chosen. No relapse of lung disease was reported in 3 months follow-up. Conclusions: Th e case reported above highlights the importance of high index of suspicion of GPA in patients with staph. aureus infections who do not respond to conventional therapy. Nasal crusts biopsy can aid diff erential diagnosis and promote early diagnosis |
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Cuvinte-cheie granulomatosis with polyangiitis, Staph. aureus, carrier, Infective endocarditis, children |
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