Metal oxides such as zinc oxide have been studied intensively as H2 sensors during of the last decade. Zn1-xCdxO is a material which presents new properties at nanometer dimensions. This work demonstrates an enhanced sensitivity performance of multiple Zn1-xCdxO nanowires-based sensor structures prepared by screen-printing technique for the detection of hydrogen at room temperature. Through Cd doping, the gas response and recovery times of multiple Zn1-xCdxO nanowires to H2 has been improved. It is shown that cadmium-doping in single-crystal zinc oxide nanowires can be used to optimize their response to gases without the requirement of external heaters.