Indirect alimentation can alter body's metabolism, as well as the levels of some blood components (hormones, lipids, etc,) that may be risk markers of morbid entities. These concepts also apply to laboratory animals, when inducing the metabolic syndromes similar to human ones. The experimental investigations aimed at creating a study on the effect of dietary interventions in the development or regression of atherosclerotic disease through the administration of a diet of purified ingredients enriched with Cholic acid and cholesterol. As source of dietary lipid served the palmitic oil which contains a high percentage of saturated fatty acids (myristic, palmitic and lauric acid). The experimental diet has resulted in an increase of the average level of cholesterol from 58,04 mg/dl on day 0 to 149,75 mg/dl on the 39th day and to 182,8 mg/dl respectively on the 93th day, with the presence of lesions in arterial preatheromatoous and dystrophic lesions (steatosis, macular degeneration, granular-microcystic, vacuolar, hyaline) in the main internal organs (liver, kidney, heart, spleen, pancreas).