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 SM ISO690:2012ROGOJIN, Vladimir, HAUTANIEMI, Sampsa. Feedback Loop Centrality to Decide Gene Essentiality in Cellular Signaling Networks. In: International Workshop on Intelligent Information Systems, 13-14 septembrie 2011, Chișinău. Chișinău, Republica Moldova: Institute of Mathematics and Computer Science, 2011, pp. 195-198. ISBN 978-9975-4237-0-0. |
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| International Workshop on Intelligent Information Systems 2011 | ||||||
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Seminarul "International Workshop on Intelligent Information Systems" Chișinău, Moldova, 13-14 septembrie 2011 | ||||||
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| Pag. 195-198 | ||||||
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We introduce the new concept of graph-node centrality measure based on feedback loops (elementary cycles) in cellular signaling networks in order to identify key genes/proteins that are essential for the malignant cellular behavior. Our hypothesis is that the essential nodes participate in many feedback loops (elementary cycles). We expect our feedback loop centrality scores may help to direct experiments to genes and complexes that most probably play a crucial role in drug resistance and invasion. Feedback loop centrality involves counting/enumerating all elementary cycles the node is participating in. Moreover, we suggest an optimization for cycle counting procedure on cellular networks. |
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| Cuvinte-cheie Node centrality measure, elementary cycle, feedback loop, signaling network, digraph, scale-free network, duplication-divergence network, cancer, malignant cell, robustness |
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