| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 623 0 |
 SM ISO690:2012KROTH, Julia, CIOLAC, Dumitru, FLEISCHER, Vinzenz, KOIRALA, Nabin, KRAMER, Julia, MUTHURAMAN, Muthuraman, LUESSI, Felix, BITTNER, Stefan, GONZALEZ-ESCAMILLA, Gabriel, ZIPP, Frauke, MEUTH, Sven G., GROPPA, Sergiu. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. In: Multiple Sclerosis Journal, 2019, nr. 3(25), pp. 338-343. ISSN 1352-4585. DOI: https://doi.org/10.1177/1352458517748474 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
 Multiple Sclerosis Journal |
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| Numărul 3(25) / 2019 / ISSN 1352-4585 | ||||||
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| DOI:https://doi.org/10.1177/1352458517748474 | ||||||
| Pag. 338-343 | ||||||
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| Rezumat | ||||||
Background: Currently, no unequivocal predictors of disease evolution exist in patients with multiple sclerosis (MS). Cortical atrophy measurements are, however, closely associated with cumulative disability. Objective: Here, we aim to forecast longitudinal magnetic resonance imaging (MRI)-driven cortical atrophy and clinical disability from cerebrospinal fluid (CSF) markers. Methods: We analyzed CSF fractions of albumin and immunoglobulins (Ig) A, G, and M and their CSF to serum quotients. Results: Widespread atrophy was highly associated with increased baseline CSF concentrations and quotients of albumin and IgA. Patients with increased CSF IgA and CSF IgM showed higher functional disability at follow-up. Conclusion: CSF markers of blood–brain barrier integrity and specific immune response forecast emerging gray matter pathology and disease progression in MS. |
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| Cuvinte-cheie atrophy rate, cerebrospinal fluid albumin, cerebrospinal fluid immunoglobulins, cortical gray matter, multiple sclerosis |
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