It was shown that water dispersed solutions of silver at concentrations of 10-9 mol/l, 10-7 mol/l, 10-5 mol/l and bismuth at concentrations of 10-7 mol/l, 10-5 mol/l, 10-1 mol/l stimulate growth of biomass and catalase activity at Penicillium funiculosum CNMN FD 11 strain. The maximum effect for the two parameters was obtained with the dispersed solution of silver at a concentration of 10-5 mol/l, bismuth at a concentration of 10-7 mg/l and zinc oxide at a concentration of 10-7 mg/l. The use of water dispersed solutions of copper at concentrations of 10-7 mg/l, 10-5 mg/l, 10-1 mg/l showed the inhibiting effect or the absence of physiological effects on growth and catalase biosynthetic processes of Penicillium funiculosum. The inhibiting effect was produced by the solution of copper at a concentration of 10-7 mg/l. The method can be used for optimising conditions for the submerse cultivation of non-pathogenic microorganisms.