This talk will be a review of the state of the art of 2D materials starting with graphene. The graphene discovery and latter of other 2D materials have produced a revolution in nanotechnology. New physical phenomena were predicted, unprecedented physical parameters such huge mobilities, extreme large Young modulus and other formidable properties have flooded the main leading scientific journal with thousands of scientific papers. The new era of great expectations started and it was believed that in few years, for example, the graphene FETs will replace Si FETs in computers and other leading applications. Today, some groups are in the phase of lost illusions. Why? The main reason was a race to fabricate the electronic devices based on semiconductors with similar devices based on graphene. In many ways, this approach was false because the graphene and other 2D materials physics is totally different compared to that of semiconductors. Therefore, the most important progress in 2D materials applications is based on devices which benefit the specific physics of 2D materials. There are still great expectations and many examples will be provided, but this requires new ways to understand nanotechnologies and their physics.