Immunohistochemical characteristic of cellular and humoral immunity and preimmune factors in chronic tonsillitis in children
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DANILOV, Lucian; ABABIY, Ivan; MANYUK, Mihail; ŞAPTEFRAŢI, Lilian; DAVID, Valeriu; FULGA, Veaceslav; BOCAN, A.. Immunohistochemical characteristic of cellular and humoral immunity and preimmune factors in chronic tonsillitis in children. In: Health Technology Management3rd International Conference. Editia 3, 6-7 octombrie 2016, Chișinău. Chișinău, Republica Moldova: Technical University of Moldova, 2016, p. 111.
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Health Technology Management
Editia 3, 2016
Conferința "Health Technology Management"
Chișinău, Moldova, 6-7 octombrie 2016

Immunohistochemical characteristic of cellular and humoral immunity and preimmune factors in chronic tonsillitis in children


Pag. 111-111

Danilov Lucian, Ababiy Ivan, Manyuk Mihail, Şaptefraţi Lilian, David Valeriu, Fulga Veaceslav, Bocan A.
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 2 aprilie 2019


Rezumat

In order to exclude errors in choosing the treatment strategy in case of chronic tonsillitis it needs to develop new contemporary diagnostic and prognostic criteria. [1, 2] The purpose of our research was to determine immunohistochemical peculiarities of the palatine tonsils during the evolution of different forms of chronic tonsillitis in children. Immunohistochemical study were subjected tissue samples taken from palatine tonsils from 21 children with compensated chronic tonsillitis and 20 children with decompensated form, the last being subdivided into two forms: without late complications and with rheumatic complications. In case of compensated chronic tonsillitis is noticed expressive suppression of Т-СD3+, Т-СD4+ and Т-СD8+ lymphocytes density with CD4+/CD8+ ratio disorder in lymph node germinal center (GC) and its peripheral area, essential decrease of humoral immunity with involvement of CD20cy+ B lymphocytes, preimmune cells (СD56+ natural killers, CD68+ macrophages) and plasma cells in this areas. Increasing of Т-СD3+ and Т-СD4+ lymphocytes level in tonsillar gaps epithelium occurs, probably, because of compensatory cell immunity stimulation in the maximal contact area with foreign antigens, at the level of lymphoepithelial barrier, following migration of this cells from other zones. For decompensated chronic tonsillitis complicated with rheumatoid pathology the following features are present: more expressive activation of cell immunity in the peripheral part of lymph node GC and in gaps epithelium, a low density of the plasma cells in GS areas and in peripheral areas of the GS, an increased number of СD20+ lymphocytes in the gaps epithelium, truthfully titres growth of CD56+ natural killer in GS, density decreasing of CD68+ macrophages in GS areas and in and in peripheral areas of the GS and their density increasing in gaps epithelium. The decrease of macrophages in GS area can be explained by their compensatory migration toward tonsillar gaps epithelium (area of antigen recognition and processing) in both forms of chronic tonsillitis, where is detected a truthful increase of their numbers in compensated chronic tonsillitis, compared to control lot. Immunohistochemical analysis of tonsils at different lymphoepithelial levels encouraged the development of new diagnostic model of local immunity particularities and assessment of the gravity of inflamatory process evolution.