Alcohol intoxication is associated with a high incidence of traumatic injury, particularly in the young healthy population. The impact of alcohol intoxication on the immediate pathophysiologic response to injury has not been closely examined. After anesthesia, a polyethylene catheter was inserted into the femoral artery and connected to a pressure transducer to monitor the mean arterial pressure (MAP).  The blood volume withdrawn was 30% of the total blood volume. EtOH + rats receivd a 3g/kg dose of 20% ethanol intraperitoneally 60 minutes before hemorrhagie. Hemodynamic parameters and cytokine assessed during the hemorrhage period (120 min). These results indicate marked alterations in the hemodynamic and metabolic responses to hemorrhagic shock by alcohol intoxication. Furthermore, our fi ndings suggest that alcohol modulates the early proinfl ammatory responses to hemorrhagic shock. Taken together, these alterations in hemodinamic and infl ammatory responses to hemorrhage are likely to impair immediate outcome and predispose to tissue injury.