Microwave assisted synthesis of some new tetranorlabdane compounds and their biological activity
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ŞMIGON, Crina; LUNGU, Lidia; ARICU, Aculina; VORNICU, Nicoleta. Microwave assisted synthesis of some new tetranorlabdane compounds and their biological activity. In: Ecological and environmental chemistry 2017The 6th International Conference. 2-3 martie 2017, Chișinău. Chisinau, Republic of Moldova: Academy of Sciences of Moldova, 2017, p. 221.
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Ecological and environmental chemistry 2017 2017
Conferința "Ecological and environmental chemistry 2017"
Chișinău, Moldova, 2-3 martie 2017

Microwave assisted synthesis of some new tetranorlabdane compounds and their biological activity


Pag. 221-221

Şmigon Crina12, Lungu Lidia12, Aricu Aculina12, Vornicu Nicoleta3
 
1 Institute of Chemistry of the Academy of Sciences of Moldova,
2 University of the Academy of Sciences of Moldova,
3 Metropolitan Center of Research TABOR, The Metropolitanate of Moldavia and Bukovina
 
Disponibil în IBN: 19 martie 2019


Rezumat

Microwave mediated organic synthesis is an environmentally friendly, safe and rapid method, which gives higher yields compared to conventional methods [1]. Thus, the microwave irradiation became very welcomed and useful for the synthesis of new biologically active compounds. According to the scheme 1, from a commercially available sclareolide 1 was obtained the hidrazide 2. The compound 2 interacted with three different aril-thiocyanates in EtOH to form the compounds 3a-c. The same reactions for the hydrazinecarbothioamides 3a-c were realised via the microwave irradiation (table 1). Therefore, the use of this method allowed us to reduce essentially the reaction time and to improve yields. The antimicrobial and antifungal activities of the compounds 3 a-c were assessed by performing “in vitro” tests against five species of fungi (Aspergillus niger, A. flavus, Penicillium chrysogenum, P. frequentans, Alternaria alternata) and two species of bacteria (Pseudomonas aeroginosa and Bacillus sp.).[2] Compound 3a showed a very good antibacterial activity, at the MIC 0.064 μg/mL in comparison with the reference compound kanamycin (3, 5 μg/ml), and antifungal activity, at the MIC 0.125 μg/mL in comparison with the reference compound caspafungin (0.24 μg/ml). The structures of compounds 3a-c were established on the basis of their 1H, 13C and 2D NMR data.