Synthesis, structure and antimicrobial activity of salicylaldehyde 4-(dimethylphenyl) thiosemicarbazones and biometal coordination compounds with these ligands

Gulya Aurelian; Erhan Tatiana; Zariciuc Elena; Petrenko Peter A.; Chumakov Yurii; Jalba Svetlana; Tsapkov Victor I.

Articolul precedent

Articolul urmator

846

Ultima descărcare din IBN:
2023-10-20 09:30

SM ISO690:2012

GULYA, Aurelian, ERHAN, Tatiana, ZARICIUC, Elena, PETRENKO, Peter A., CHUMAKOV, Yurii, JALBA, Svetlana, TSAPKOV, Victor I.. Synthesis, structure and antimicrobial activity of salicylaldehyde 4-(dimethylphenyl) thiosemicarbazones and biometal coordination compounds with these ligands. In: Ecological and environmental chemistry : - 2017, Ed. 6, 2-3 martie 2017, Chișinău. Chisinau, Republic of Moldova: Academy of Sciences of Moldova, 2017, Ediția 6, p. 215.

EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core

Ecological and environmental chemistry
Ediția 6, 2017

Conferința "Ecological and environmental chemistry 2017"
6, Chișinău, Moldova, 2-3 martie 2017

Synthesis, structure and antimicrobial activity of salicylaldehyde 4-(dimethylphenyl) thiosemicarbazones and biometal coordination compounds with these ligands

Pag. 215-215

Gulya Aurelian¹, Erhan Tatiana², Zariciuc Elena², Petrenko Peter A.³, Chumakov Yurii⁴³, Jalba Svetlana¹, Tsapkov Victor I.¹

¹ Moldova State University,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
³ Institute of Applied Physics, Academy of Sciences of Moldova,
⁴ Gebze Technical University

Proiecte:

Menționat în lucrare: 16.00353.50.02.A Materiale avansate in biofarmaceutica.Sinteza chimica, proprietati anticancer si antibacteriene

Disponibil în IBN: 19 martie 2019

Descarcă PDF

Rezumat

The aim of this work is the synthesis of salicylaldehyde 4-(dimethylphenyl)thiosemicarbazones (H2L) and cobalt, nickel, copper, and zinc coordination compounds with these ligands, determination of their composition, structure and antimicrobial activity. First, the thiocarbamides were obtained by the reaction of dimethylanilines with DTMT. Then thiosemicarbazides were obtained by a one or two step process. Finally, thiosemicarbazones H2L were synthesized by the condensation of corresponding thiosemicarbazide with salicylaldehyde. The purity of all organic substances was proved by NMR (1H and 13C) spectroscopy. The single crystals of some substances were obtained and their structures were determined by X rays diffraction analysis. These molecules represent almost planar structures. The ethanol solutions of chlorides of stated above metals react with thiosemicarbazones H2L in 1:1 or 1:2 molar ratio forming coordination compounds M(HL)Cl (M = Cu, Zn), Ni(HL)2 and Co(HL)2Cl. Their structures were determined using IR spectroscopy and magnetochemical measurements. In case of nickel and cobalt complexes structures were proved by X-rays diffraction analysis. All substances are monomeric. The thiosemicarbazones H2L acts as threedentate ONS-ligands. The antimicrobial activity of these compounds was studied in vitro using the method of two-fold serial dilutions in liquid nutrient medium on standard strains of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Both thiosemicarbazone and biometal coordination compounds manifest selective antimicrobial activity in the range of concentrations 0,7 – 1000,0 mg/mL. The nickel coordination compounds are the most active substances from this series. The antimicrobial activity depends on the nature of the central atom and positions of the methyl groups in the thiosemicarbazide moiety. Identified properties of thiosemicarbazones and biometal coordination compounds with these ligands are of interest in terms of expanding the arsenal of the reserve disinfectants. They can be used in the case of microbial immunity to traditional medicines.

Crossref XML Export

<?xml version='1.0' encoding='utf-8'?>
<doi_batch version='4.3.7' xmlns='http://www.crossref.org/schema/4.3.7' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd'>
<head>
<doi_batch_id>ibn-74256</doi_batch_id>
<timestamp>1713403597</timestamp>
<depositor>
<depositor_name>Information Society Development Instiute, Republic of Moldova</depositor_name>
<email_address>idsi@asm.md</email_address>
</depositor>
</head>
<body>
<collection>
<collection_metadata>
<full_title>Ecological and environmental chemistry </full_title>
</collection_metadata>
<collection_issue>
<publication_date media_type='print'>
<year>2017</year>
</publication_date>
</collection_issue>
<collection_article publication_type='full_text'><titles>
<title>Synthesis, structure and antimicrobial activity of salicylaldehyde 4-(dimethylphenyl) thiosemicarbazones and biometal coordination compounds with these ligands</title>
</titles>
<contributors>
<person_name sequence='first' contributor_role='author'>
<given_name>Aurelian</given_name>
<surname>Gulea</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Tatiana</given_name>
<surname>Erhan</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Elena</given_name>
<surname>Zariciuc</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Piotr</given_name>
<surname>Petrenko</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Iurie</given_name>
<surname>Ciumacov</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Svetlana</given_name>
<surname>Jalba</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Victor</given_name>
<surname>Ţapcov</surname>
</person_name>
</contributors>
<publication_date media_type='print'>
<year>2017</year>
</publication_date>
<pages>
<first_page>215</first_page>
<last_page>215</last_page>
</pages>
</collection_article>
</collection>
</body>
</doi_batch>