The complex studies of structural, metabolical and functional changes in gametes during the cryconservation process gave us the opportunity to discover many aspects of cryodestruction mechanisms and to develop methods of medium and long-term storage of cell suspensions of biological material of different species of farm animals. However, the existing cryopreservation technologies do not allow the exploitation of the full genetic potential, so the aim of the research was to study the general and species-specific physiological and biochemical reactions in the animal genome cryopreservation. During the performed study, special attention was paid to the nature of the cryogenic changes in physiological and biochemical parameters of semen of bulls, sheep, hogs, roosters and carp, and, particularly, whether they are specific to the semen of a particular species or are common to all types of the tested animals. Such analysis is essential because it permits to carry out a targeted selection of the cryoconservation stabilizers of functional gametes of a particular species. It was found out that certain changes of parameters of semen during the conservation are common for all animal species – they are non-specific, and others hold species dependent differences – they are species-specific. The different responses of animal gametes to the impact of environmental factors can be explained by the peculiarities of their biochemical parameters. It should also be noted that even non-specific changing parameters, can hold species-dependent differences, which comes out as varying degrees of modification of these parameters. Naturally, the question of the role of certain biochemical parameters in the development of destructive processes of gametes arises and whether all the modifications we identified are related to the destruction of gametes, or some of them show the manifestation of the protective reaction. Understanding the complexity of the issue, we have tried to distinguish some protective biochemical parameters against the destructive reactions. However, without the solution of this problem the concept of targeted influence on certain parameters, which are changing in the process of preservation, can not be developed. However, if the modification of a parameter is not due to the defense mechanisms, but destructive mechanisms, then stabilizing them will not lead to the maintenance of the structural and functional homeostasis of gametes, but rather to its violation. Cryogenic changes of specific nature causes a complex of compensatory-adaptive processes in cryobiological systems and the possibility of full or partial rehabilitation of the object after cryopreservation, and also allows to set the dependence between the effectiveness of the combined use of the various components of cryoprotective mediums and morpho-functional characteristics of spermatozoa. Thus, cryodestruction of gametes of different species of animals takes place in both ways: through general and species-specific response. Although in many respects the occurrence of cryodestruction processes during freezing-thawing is of a general nature, it is generally caused by species-specific changes of structural-biochemical homeostasis.