The immune response on pulmonary tuberculosis consists in the activation of T lymphocytes, macrophages and the subsequent distribution of macrophages IFN-γ. It leads to the formation of granuloma, which allows limiting the spread of mycobacteria. The ability of CD4 and CD8 lymphocytes to destroy intracellular mycobacteria depends on their contact with infected cells and capabilities to secrete cytolytic and antibacterial molecules [Stegelmann F., et al. 2005]. The purpose of our research was to study the dynamics of Th1, Th2 immune response indices in patients with pulmonary tuberculosis under the influence of the immune corrective treatment. The study included 45 patients with pulmonary tuberculosis who received the standard anti-tuberculosis treatment and immune corrective therapy with silymarin. The patients were examined before and after the treatment. The content of lymphocytes, of CD3 using Flow Cyto- mertrie (Partec PAS I), of IFN-γ cytokine, IL-10 using ELISA sets of the company «Vector- Best» (Russia) were determined in all patients. The content of INFγ, cytokine Th1 type (see Table) before the treatment was significantly higher than in healthy persons (p <0.001), after the treatment the rate was significantly decreased (p<0.001), but was still remained significantly higher than in healthy persons (p<0.01). The content of IL-10, a cytokine Th2 type before the treatment was slightly higher than in healthy persons, but not authentically. After the treatment this index was decreased, but not authentically. It means that in patients with tuberculosis the Th1 type of immune response was observed. This is confirmed by a significantly lower content of lymphocytes before the treatment (less than in healthy persons - p<0.001). After the treatment the content of lymphocytes was significantly increased (p<0.01), but remained significantly lower than in healthy persons (p<0.01). The content of CD3 lymphocytes before the treatment was also significantly lower than in healthy persons (p<0.001). The content of CD3 lymphocytes after treatment was significantly increased (p<0.01) and was not significantly different from the index in healthy persons. Thus, the Th1 type of immune response with a pronounced deficiency of lymphocytes CD3 is determined in patients with pulmonary tuberculosis. Even after the treatment not all investigated indicators have returned to normal parameters.