Disorders of carbohydrate metabolism play an important role in the pathogenesis of many diseases, therefore are particularly valuable the attempts of pharmacological correction with local bioactive compounds. The purpose of the research was to investigate the influence of some local bioactive compounds (BAC) on carbohydrate metabolism in cyclophosphan induced experimental hepatopathy (HP), and to bring arguments of their utility in preventing and treating liver disorders. The HP was induced by the administration of cyclophosphan (CP). Carbohydrate metabolism markers: isoforms of lactate dehydrogenase – LDH-L (catalyzes the conversion of lactate into pyruvate) and the LDH-P (catalyses the conversion of pyruvate to lactate), as well as the activities of glucose-6-phosphate dehydrogenase (G-6-PDH), and NADP-dependent malate dehydrogenase (MDH NADPd) were determined in the liver. HP medication was performed using local BAC – cyanobacterial remedies PSS (50 mg/kg and 125 mg/kg) and BioR-Ge. Changes of the carbohydrate metabolism in the liver of the animals with hepatopathy induced by cyclophosphan, and the influence of the local BAC are presented in the table below. Toxic doses of ciclofosfan causes significant increase of LDH-L by 71% (p<0.05) and LDHP by 28% (p<0.05), which probably reflects the acceleration of aerobic glycolysis oriented to compensate the cellular energy deficiency of the liver in cyclophosphan induced experimental hepatopathy. All tested remedies reduced LDH-L and LDH-P activities, but only PSS 125 mg/ kg and BioR-Ge restore the normal values. G-6-PDH activity was reduced without statistical significance by 19% in animals intoxicated with ciclofosfan. PSS (125 mg/kg) administration inducde the activity of G-6-PDH by 48% (p<0.05) compared to untreated HP reaching values by 19% higher then the reference one. At the same time changes of MDH NADHd in all study groups were found to be inconclusive. Studied BAC had a positive effect on the carbohydrate metabolism, which was characterized by the tendency of normalization of the LDH isoforms activity, especially by BioR-Ge and the increase of G-6-PDH activity by PSS 125 mg/kg. The studied BAC can be used as remedies for correction of metabolism disorders caused by toxic liver injury.