In the present paper were evaluated the dynamics, the structure of influenza morbidity and the influenza vaccination of professional contingents with an elevated level of disease among the population of the Republic of Moldova in 44 administrative territories (4 municipalities and 40 districts (including the eastern districts)) during the period 2007–2015. The objective of the study was the assessment of the dynamics and structure of influenza morbidity and flu vaccination in the population of the Republic of Moldova during 2007–2015 years. The present study is a retrospective, descriptive, longitudinal study, based on the analysis of statistical report: form No.2 “Statistical Report on infectious and parasitic diseases” and No.5 “Report on preventive vaccination” elaborated by the National Center of Public Health from the Republic of Moldova. In the Republic of Moldova, during the period 2007–2015, were recorded a total of 59 036 cases of influenza, of which 23 321 (39.5%) cases were reported among children aged 0–17 years. The trend incidence of this respiratory infection during nine years is decreasing. The highest rate was recorded in 2009 (517 cases per 100.000 population and 10,5 cases per 1000 children) and the lowest in 2012 (8,3 cases per 100.000 population and 0,2 cases per 1000 children). Also, about 65.3% of cases of influenza among adults and 60.2% among children were recorded in urban areas and 34.7% cases among adults and 39.8% among children were from rural areas. The structure of morbidity according the age among children aged 0–17 years is as follows: 0–2 years – 11.3%, 3–6 years – 22.6% (three fifths of them being institutionalized) and 7–17 years – 66.1%. The campaign of influenza vaccination of professional contingents with an elevated level of disease in the 2014–2015 season covered 87.18% (from 172052 people who needed to be vaccinated were vaccinated 150000), in the season 2015–2016 100% coverage. The development of strong competences in the promotion of a healthy lifestyle is conducted by students of the microbiological scientific-practical circle with strategies for prevention of influenza and activities to encourage immunization through vaccination. In conclusion, during the past nine years in the Republic of Moldova there is a decrease of the incidence of influenza morbidity, which demonstrates the effectiveness of immunization of the population with anti-influenza vaccine. Cases of influenza are predominant in urban areas to people aged over 17 years. Seasonal influenza immunization covered only 4.3% of the total population in the past two years, which proves that the immune percentage is insufficient.