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SM ISO690:2012 SUWINSKA, Kinga. Calixarenes as potential drugs carriers. In: Materials Science and Condensed Matter Physics, Ed. 7, 16-19 septembrie 2014, Chișinău. Chișinău, Republica Moldova: Institutul de Fizică Aplicată, 2014, Editia 7, p. 127. |
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Materials Science and Condensed Matter Physics Editia 7, 2014 |
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Conferința "Materials Science and Condensed Matter Physics" 7, Chișinău, Moldova, 16-19 septembrie 2014 | ||||||
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Pag. 127-127 | ||||||
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The design and synthesis of water-soluble, synthetic macrocycles as artificial receptors and biomimetic models for enzymes has been a major subject of interest in recent years. Self-assembly of such synthetic receptors with biorelevant molecules is a powerful tool for the understanding, modeling and mimicking of biological systems and developing new materials with specific properties and functions. Along with cyclodextrins, crown ethers and cryptands, calix[n]arenes are one of the most important categories of supramolecular hosts. It is well known that biogenic amines, amino acids, peptides, and proteins constitute one of the most fundamental substrates in biological and artificial processes. The family of calix[n]arenes is deeply involved in molecular recognition of these compounds, especially in the understanding of specific biomolecular interactions which play a key role in modern supramolecular chemistry. Water-soluble calixarenes are of interest in building up systems that mimic natural biological processes through the presence of hydrophobic pockets which can bind nonpolar guests. Moreover, they themselves were also demonstrated to possess useful potential bio-activities ranging from enzyme inhibition through antithrombotic activity and antiviral activity to antibacterial properties. The aim of this presentation is to summarize the up-to date knowledge about the solid-state interactions of complexes of certain water-soluble calix[n]arenes with drug molecules. |
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