Heavy metals (HM) are most prevalent pollutants of various environmental components, including soils. In food chains, NM alter considerably the intensity of plant metabolic processes (in particular photosynthesis), reducing their productivity and crop quality. It is known, that microorganisms, as mediators between soil conditions and plants, can increase significantly the resistance of macrosymbiont to stress. In this regard, an integrated approach is need to the study of microbial-plant associations. The investigation of physiological and biochemical parameters of plants, in particular the components of lipid-pigments complex, is an integral index of physiological state of plants and of their adaptive potential. The aim of our research was to evaluate the influence of microbial preparation Phosphoenterin on the components of lipid-pigment complex of winter wheat in the early stages of plant development under the impact of HM. Vegetation experiments were conducted in a greenhouse on winter wheat - Triticum durum L., 5-fold repetition. The preparation Phosphoenterin was used for the inoculation of seeds prior to sowing (control – no inoculated). Plants have been cultivated for 6 weeks in pots (1000 ml) on southern carbonate chernozem. In each pot were added and thoroughly mixed with soil solutions of HM salts: Pb(CH3COO)2, CuSO4, K2CrO4 (levels of HM pollution 1 and 5 MPC), the control – without HM. The results of our experiments indicate the negative impact of HM on components of lipidpigment complex in leaves of winter wheat in early stages of ontogenesis. The pollution of soil by HM at 1 MPC reduced the content of chlorophylls a and b in leaves by 2.6 and 1.7 times (to 0.0719 and 0.0408 mg/g, respectively) in comparison with the control, and at 5 MPC – by 4 and 3.5 times (to 0.0468 and 0.0205 mg/g, respectively). The negative influence of HM on the synthesis of carotenoids in leaves of wheat also have been revealed – their content decreased more than 2 times compared to the control (0.0250 mg/g against 0.0588 mg/g). The positive influence of pre-sowing inoculation was established on the content of chlorophylls in the leaves of plants grown on HM contaminated soil: chlorophyll a - by 21% (1 MPC) and 8% (5 MPC), and chlorophyll b - by 32% (1 MPC) and 4% (5 MPC) in comparison with the control. The total content of chlorophylls (a+b) in the leaves of inoculated plants exceeded the control by 25% (1 MPC) and 7% (5 MPC), carotenoids – by 44% (1 MPC) and 5% (5 MPC). The membrane structure of plastids contains the sulfolipids, which support the optimal level of photosynthetic processes in chloroplasts. The negative impact of HM on this component of lipid complex in leaves has been established. Thus, soil contamination of HM at 1 and 5 MPC reduced the content of sulfolipids in leaves by 16% and 31% respectively, compared to control. In leaves of inoculated plants their content increased by 12% (1 MPC) and 5% (5 MPC) in comparison with control. The negative influence of HM on the functioning of the lipid-pigments complex of winter wheat reduced the productivity and height of plants: their mass decreased by 10% and 51% (1 and 5 MPC respectively), height (5 MPC of HM) – by 30%. Inoculation contributed to reduction of stress effects of HM: theirs negative influence on plants was no revealed at the level of 1 MPC contamination of soil; and at 5 MPC – the mass and height of inoculated plants decreased only by 29% and 10%, respetively. Thus, the positive effect of pre-sowing inoculation of seeds (Phosphoenterin) on the components of lipid-pigments complex in leaves of winter wheat in early stages of plant ontogenesis was revealed, which improved their adaptive potential to HM stress impact.