In order to determine the inclusion of coordination compounds in biosynthetic activity of cyanobacterium Spirulina platensis, it was studied changing the protein content into biomass in the presence of zinc acetate under hypothermic conditions of short duration. Hypothermic stress was induced by maintaining spirulina cultivation at 40C over a period of 1, 2 and 3 hours. Spirulina has been subjected to hypothermic stress in the early lag phase or 1 day culture for, at the beginning of exponential phase or 3 days culture and at the end of exponential phase or 6 days culture. Spirulina has been grown under optimum conditions in the presence of zinc acetate in concentration of 15 mg/l. This compound was supplemented to mineral medium from the first day of cultivation. It was used as control sample spirulina of appropriate age, grown under optimal conditions (continuous illumination, temperature 28-320C) in the absence of chemical stimulator and in the presence of chemical stimulators. Conditions of hypothermia were induced for culture of spirulina grown in the absence and presence of zinc acetate. Fe (III) alalinate has stimulated the accumulation of phycobilins during the exponential phase of spirulina grown under optimum conditions. By the end of exponential phase, phycobilin content was with 25% higher compared to control. In spirulina, grown under optimum conditions in the absence of Fe (III) alalinate and subjected to short-duration hypothermia, phycobilin content increased insignificantly with extending the exposure to low temperatures. The presence of Fe (III) alalinate caused the reduction of phycobiliprotein content in spirulina biomass during the action of low temperatures. In spirulina culture, at the beginning of lag phase, grown in the presence of [Fe(III)-ala], hypothermic conditions have changed essentially phycobilin content in biomass, which were reduced by 21% after the first hour of heat stress and 1.6 times after three hours of exposure to 40C. Phycobilin content decreased of 4.3 times in spirulina culture in exponential phase and subjected to hypothermic stress for one hour. Two hours of hypothermia resulted in decrease of 2.9 times of phycobilins in biomass, and exposure of spirulina to further heat stress reduced by 3.7 times their concentration. In spirulina biomass in stationary phase that has been cultivated in the presence of compound Fe (III) alanine, one hour of hypothermia caused a decrease of 5.4 times of phycobilin content. While three hours of hypothermic stress caused a more moderate reduction, 3.2 times, of phycobilin content in spirulina biomass. Therefore, stimulation effect of Fe (III) alalinate on phycobilin synthesis was annihilated by extreme temperatures. The most vulnerable has proved to be the culture of spirulina in exponential growth phase and also stationary phase that significantly lost the content of phycobilins after the first hour of hypothermic stress. Fe(III) alalinate from cultivation medium did not alter phycobiliprotein synthesis in spirulina in adaptation period, which being subjected to hypothermic stress does not change their content. In the case of spirulina at the beginning of exponential phase and stationary phase, iron compound involved in vital processes reorienting biosynthetic activity of spirulina, which under hypothermic conditions, reduced phycobiliprotein content after the first hour of exposure to low temperatures.