Nowadays, it is well known that animals bred under farm conditions are subject to technological stress. Therefore, the productivity and quality of the products obtained from such animals decrease. A decrease in the productivity and quality also takes place using a wide range of drugs, many of which are unsafe for animals and humans. A number of studies suggest that, from a wide range of natural products that exhibit therapeutic and productive effects, a larger perspective present those obtained from microalgae. Therefore, a huge theoretical and practical interest presents the study of the mechanisms of action of biologically active substances of natural origin, in particular of the BioR remedy, obtained by modern technologies from Spirulina platensis, on the clinical and hematological status, as well as on the productivity of adult quails placed under reconditioning.– Butofan, is of. The research of the biological activity of the above mentioned remedy was carried out in a comparative study with Butofan and physiological serum (sol. 0,9% NaCl), on a group of 150 adult quails, at the end of the laying cycle, put under reconditioning, belonging to the English White breed, weighting 296,4-301,0 g, and divided into 3 lots, 50 birds each. All three lots of quails were set up randomly, while respecting the principle of analogy. All the mentioned remedies were administered intramuscularly, in the same place - the pectoral muscles. For hematological investigations, at the onset of the study, 5 blood samples were collected, and during the study (at the 28th day), as well as at the end of the experiment (at the 50th day), 5 blood samples were taken from each lot. The quails were weighed individually, at different stages of the study (at 10-14 days), and on a daily basis, the eggs were collected and counted. The BioR and Butofan remedies, during the 50-day study, did not cause any adverse effects or other deviations on quail’s health. It has been established that both the clinical and hematological parameters investigated manifested positive tendencies. Thus, the tested remedies exhibited adaptive and antistress properties, reflected also in lower body temperature at the end of the study: in the lot treated with BioR, by 0,32oC, and in the lot treated with Butofan, respectively by 0,18oC in relation to the reference lot. These are considered to be good results for both remedies, and in particular for the BioR remedy. Similar results regarding quail body temperature and respiratory movements have been reported. Studies have shown that the hematological parameters investigated: RBC, HB, HCT, MCV, MCH and MCHC, both for intact quails and the experimental groups, do not show major deviations throughout the study. In addition, the obtained results highlight the fact that the tested remedies show good results regarding the values of the investigated parameter in this category of birds. A special place in testing drug remedies on animals also has the study of the productive parameters. In our study, the evolution of the body weight in quails had a negative dynamic. The body weight loss in birds from the reference group was of 16,46 g, and in the groups treated with BioR and Butofan of 5,2 g, and 8,76 g, respectively. The laying qualities of the quails treated with the remedies taken in the study were superior to those in the reference group. In conclusion, we underline the fact that the tested remedies, especially BioR, show positive health and productive effects on adult quails put under reconditioning.