Bacteriostatic and bactericide activities of some 3D metal complexes with 2-[2-(prop-2-en-1-ylcarbamothioyl)-hydrazinylidene] propanoic acid
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GRAUR, Vasile; TSAPKOV, Viktor; DIURICI, E.; BALAN, Greta; BURDUNIUC, Olga; GULEA, Aurelian; RUDIC, Valeriu. Bacteriostatic and bactericide activities of some 3D metal complexes with 2-[2-(prop-2-en-1-ylcarbamothioyl)-hydrazinylidene] propanoic acid. In: Microbial Biotechnology. Ediția 4, 11-12 octombrie 2018, Chișinău. Chișinău, Republica Moldova: Institutul de Microbiologie şi Biotehnologie, 2018, pp. 65-66. ISBN 978-9975-3178-8-7.
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Microbial Biotechnology
Ediția 4, 2018
Conferința "Microbial Biotechnology"
Chișinău, Moldova, 11-12 octombrie 2018

Bacteriostatic and bactericide activities of some 3D metal complexes with 2-[2-(prop-2-en-1-ylcarbamothioyl)-hydrazinylidene] propanoic acid


Pag. 65-66

Graur Vasile1, Tsapkov Viktor1, Diurici E.1, Balan Greta2, Burduniuc Olga3, Gulea Aurelian1, Rudic Valeriu4
 
1 State University of Moldova,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 National Agency for Public Health,
4 Institute of Microbiology and Biotechnology
 
Disponibil în IBN: 19 februarie 2019



Teza

Pyruvic acid thiosemicarbazones, their derivatives and 3d metal coordination compounds with these ligands manifest anticancer, antimicrobial, and antifungal properties. Therefore, the aim of this work is to determine the influence of introduction of the allyl moiety in the fourth position of the thiosemicarbazide fragment on biological properties of the corresponding thiosemicarbazone (H2L) and biometal coordination compounds with this ligand. Iron, cobalt, nickel, and copper salts react with pyruvic acid 4-allylthiosemicarbazone (H2L) forming coordination compounds: Cu(HL)X (X=Cl-, Br-, NO3 -); Cu(H2O)(L); Cu(A)(L) (A = imidazole (Im); 3,4-dimethylpyridine (3,4-Lut)); M(HL)2X (M=Fe3+, Co3+; X=Cl-, Br-, NO3 -) and Ni(HL)2. The composition of these coordination compounds was determined using elemental analysis. Their structures were studied using magnetochemical research, IR spectroscopy, and X-ray diffraction analysis. The antimicrobial activity of these compounds was studied in vitro using the method of two-fold serial dilutions in liquid nutrient medium (meat infusion broth, pH = 7.0). The substances were dissolved in DMSO in such amounts that the solutions of concentration 10 mg / mL were obtained. The next dilutions were made using meat infusion broth. The antimicrobial activity was tested on standard strains of gram-positive (Staphylococcus aureus ATCC 25923), gram-negative (Escherihia coli ATCC 25922) bacteria and Candida albicans. It was found that pyruvic acid 4-allylthiosemicarbazone (H2L) shows neither bacteriostatic nor bactericide activities towards gram-positive and gram-negative microorganisms, but it inhibits the growth of Candida albicans at 500 μg / mL concentration. The coordination of the thiosemicarbazone H2L to 3d metal ions changes the biological activity. The synthesized coordination compounds manifest antimicrobial and antifungal activities. The minimal inhibitory and bactericide concentrations are in the range of 31.25 - 1000 μg / mL. The nature of the metal ion has the main influence on the antimicrobial activity of these coordination compounds. The antimicrobial activity significantly growth in case of copper(II) complexes. The introduction of amines in the inner sphere of copper coordination compounds also leads to the growth of inhibitory and bactericide activity. The nature of acid residue does not significantly affect the biological activity of the synthesized substances. Complexes Cu(HL)Br and Cu(Im)(L) show the highest antifungal activity. The determinated properties of the synthesized biometal coordination compounds with pyruvic acid 4-allylthiosemicarbazone are of interest for medical practice for enhancement of the arsenal of antimicrobial and antifungal preparations.