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USATAIA, Irina; GRAUR, Vasile; TSAPKOV, Victor; VASYLCA, M.; BALAN, Greta; BURDUNIUC, Olga; GULEA, Aurelian. Antibacterial and antifungal activities of iron(III), cobalt(III), nickel(II) and copper(II) coordination compounds with 3,5-dibromosalicylaldehyde 4-allyls-methylisothiosemicarbazone. In: Microbial Biotechnology. Ediția 4, 11-12 octombrie 2018, Chișinău. Chișinău, Republica Moldova: Institutul de Microbiologie şi Biotehnologie, 2018, pp. 57-58. ISBN 978-9975-3178-8-7.
Ediția 4, 2018
Conferința "Microbial Biotechnology" |
Chișinău, Moldova, 11-12 octombrie 2018
The search for novel biologically active substances with more selectivity and lower toxicity continues to be an area of intensive investigation. Isothiosemicarbazones have not been studied extensively from a biological point of view. The introduction of methyl group on the sulfur atom leads to a change of the method of coordination and biological properties. Iron(III), cobalt(II), nickel(II), and copper(II) salts react with 3,5-dibromosalicylaldehyde 4-allyl-S-methylisothiosemicarbazone (HL) forming coordination compounds with composition: Cu(L)X (X=Cl-, Br-), M(L)2X (M=Fe3+, Co3+; X=I-, NO3 -, CH3COO-); Ni(L)2. The antibacterial and antifungal activities of these compounds were studied in vitro using the method of two-fold serial dilutions in liquid nutrient medium (meat infusion broth, pH = 7.0). The substances were dissolved in DMSO in such amounts that the solutions of concentration 10 mg / mL were obtained. The next dilutions were made using meat infusion broth. The antibacterial activity was tested on standard strains of gram-positive (Staphylococcus aureus ATCC 25923), gram-negative (Escherichia coli ATCC 25922) microorganisms. The antifungal actitivity was studied on Candida albicans. It was determined that HL isothiosemicarbazone manifests antifungal activity against Candida albicans and bacteriostatic activity towards only gram-positive bacteria. The nature of the central atom has the main influence on antimicrobial activity of the synthesized coordination compounds. The antibacterial activity against gram-positive microorganisms significantly growth in case of copper coordination compounds. Iron, cobalt and nickel coordination compounds have practically the same biological activity as the corresponding isothiosemicarbazone. Only cobalt coordination compounds manifest a weak antimicrobial activity against gram-negative microorganisms.