Recently, a lot of scientific work has been devoted to the study of endogenous intoxication in various pathological diseases and conditions. Endogenous intoxication is one of the most important criteria determining the severity of a person condition (Разнатовская Е.Н., 2012). In this regard, the use of drugs in order to detoxify the body and normalize the changed immune status of patients has a particular importance in modern complex therapy of tuberculosis. The aim of the work was to study the indices of endogenous intoxication in patients with pulmonary tuberculosis under the influence of immunomodulators. Material and methods. The study included 57 patients with pulmonary tuberculosis with sensitivity to anti-TB drugs. The first group (38 patients) received concurrently BioR with anti- TB drugs. The second group consisted of 19 patients who, for various reasons, received only anti-tuberculosis treatment. Indices of endogenous intoxication were determined by the new method proposed by authors (Ghinda S. şi coaut. 2015). Analysis and discussion of the results. The content of circulating immune complexes (CICs) was not the same for patients of different groups (see the table). The content of the CICs with high molecular weight (PEG 2.5%) and having low toxicity in patients of both groups was not significantly different on admission and was significantly lower (p<0.001 in both groups) than in healthy ones. After treatment, the content of the CICs with a high molecular weight (PEG 2.5%) decreased, but only in the first group this decrease was significant (p <0.01). The content of the CICs with an average molecular weight (PEG 4.2%), which had the greatest toxicity, was not significantly different in admission in patients of both groups and was significantly less (p<0.001 in both groups) than in healthy ones. After treatment, the content of the CICs with an average molecular weight (PEG 4.2%) was reliably reduced, with approximately the same intensity in both groups (p<0.05). The content of the CICs with a small molecular weight (PEG 8.0%) and high toxicity in patients of both groups was not significantly different on admission and was significantly less (p <0.001 in both groups) than in healthy ones. The content of CICs with an average molecular weight (PEG 4.2%) decreased after treatment, but only in the first group this decrease was significant (p<0.01). Conclusion: The use of the BioR preparation in the complex treatment of tuberculosis, with adaptogenic, antioxidant, immunoregulating and detoxifying properties, makes it possible to combat the syndrome of endogenous intoxication more effectively.