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SM ISO690:2012 VLĂDESCU, Andreea, VRANCEANU, D., PARAU, A. C., COTRUT, C., KISS, A., CONSTANTIN, L., BRAIC, V.. In vitro investigation of ag doped hydroxyapatite coatings in different acellular media. In: Materials Science and Condensed Matter Physics, Ed. 9, 25-28 septembrie 2018, Chișinău. Chișinău, Republica Moldova: Institutul de Fizică Aplicată, 2018, Ediția 9, p. 222. |
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Materials Science and Condensed Matter Physics Ediția 9, 2018 |
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Conferința "International Conference on Materials Science and Condensed Matter Physics" 9, Chișinău, Moldova, 25-28 septembrie 2018 | ||||||
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CZU: 539.2+621.38+57.08:615 | ||||||
Pag. 222-222 | ||||||
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Bone healing around implants involves a cascade of biological events that take place at the bone-biomaterial interface until the biomaterial surface appears covered with a newly formed bone [1, 2]. The biomaterials functionality into the human body is driven not just by meeting all the requirements in terms of chemical, physical and mechanical proprieties and also by their interaction and behaviour with the human body in terms of biocompatibility, degradation and bioactivity which are important processes, subsequently involved in the osseointegration of metallic implants. In the previous papers, we have demonstrated that a small Ag addition (1 at. %) into sputtered hydroxyapatite coatings is sufficient for improving the resistance to Candida albicans infection [3] as well to Staphylococcus aureus, Salmonella Typhimurium or Streptococcus pyogenes [4]. This paper aims to study the effect of Ag addition into hydroxyapatite through in vitro evaluation in acellular media in terms of bioactivity and degradation. To our knowledge, results concerning these two specific abilities of Ag doped hydroxyapatite prepared by magnetron sputtering are not yet reported. For this paper, in vitro tests were performed in simulated body fluid (SBF), Dulbecco's Modified Eagle's medium (DMEM) and phosphate buffer solution (PBS) over a period ranged from 1 to 21 days of immersion at 37 ±0.5°C. Also the corrosion investigations in all three acellular media were carried out at 37 ±0.5°C. |
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