Investigation of the cytotoxic potential of methyl imidazole-derived thiosemicarbazones and their copper(ii) complexes with dichloroacetate as a co-ligand
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
73 0
SM ISO690:2012
PALAMARCIUC, Oleg; MILUNOVIC, Miljan; SÎRBU, Angela; STRATULAT, Elena; PUI, Aurel; GLIGORIJEVIĆ, Nevenka ; RADULOVIC, Sinisa; KOZISEK, Jozef; DARVASIOVA, Denisa; RAPTA, Peter; ENYEDY, Eva Anna; NOVIŢCHI, Ghenadie; SHOVA, Sergiu; ARION, Vladimir. Investigation of the cytotoxic potential of methyl imidazole-derived thiosemicarbazones and their copper(ii) complexes with dichloroacetate as a co-ligand. In: New Journal of Chemistry. 2019, nr. 3(43), pp. 1340-1357. ISSN 1144-0546.
EXPORT metadate:
Google Scholar
Crossref
CERIF
BibTeX
DataCite
Dublin Core
New Journal of Chemistry
Numărul 3(43) / 2019 / ISSN 1144-0546

Investigation of the cytotoxic potential of methyl imidazole-derived thiosemicarbazones and their copper(ii) complexes with dichloroacetate as a co-ligand


DOI: 10.1039/c8nj04041a
Pag. 1340-1357

Palamarciuc Oleg1, Milunovic Miljan23, Sîrbu Angela1, Stratulat Elena1, Pui Aurel4, Gligorijević Nevenka 5, Radulovic Sinisa5, Kozisek Jozef3, Darvasiova Denisa3, Rapta Peter3, Enyedy Eva Anna6, Noviţchi Ghenadie7, Shova Sergiu8, Arion Vladimir9
 
1 State University of Moldova,
2 Medical University of Vienna,
3 Slovak University of Technology,
4 „Alexandru Ioan Cuza” University, Iasi,
5 Institute of Oncology and Radiology of Serbia,
6 University of Szeged,
7 Laboratoire National des Champs Magnétiques Intenses, UPR CNRS, Grenoble,
8 “Petru Poni” Institute of Macromolecular Chemistry,
9 Universitatea din Vienna
 
Disponibil în IBN: 1 februarie 2019


Rezumat

A series of six imidazole-derived thiosemicarbazones (HL1-HL6) and their copper(ii) complexes (1-6) were synthesised and characterised by analytical, spectroscopic, electrochemical and single crystal X-ray diffraction techniques. In addition, solution studies and the results of antiproliferative activity in human cancer cell lines with some insights into the mechanism of cancer cell death are also reported. In particular, the substitution of one hydrogen at the terminal N-atom of the thiosemicarbazide moiety by a phenyl group resulted in slightly enhanced antiproliferative activity. HL3 and HL6 showed lower IC50 values compared to HL1 and HL4 in MDA-MB-453 and LS174 cancer cell lines. The copper(ii) complexes 3 and 6 exhibit a 2.4- and 4.7-fold increase of activity compared to parent proligands in MDA-MB-453 cancer cell line, respectively. The complex formation of the proligands with copper(ii) increased their antiproliferative activity in all investigated cell lines. The cell cycle perturbations, apoptotic potential and the analysis of morphological changes in the A549 cell line induced by 3 and 6 revealed cytostatic rather than cytotoxic effects.