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Articolul urmator |
547 7 |
Ultima descărcare din IBN: 2023-10-18 15:01 |
SM ISO690:2012 GULYA, Aurelian, ZARICIUC, Elena, POIRIER, Donald, TSAPKOV, Victor I., RUDIK, V.. Synthesis, antimicrobial and antitumor activity of copper(II) salicylidene- and naphthalidene-4-alkylthiosemicarbazidates containing sulphanilamides. In: The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova, 28-30 mai 2014, Chișinău. Chișinău, Republica Moldova: Institutul de Chimie al AȘM, 2014, p. 129. |
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The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova 2014 | ||||||
Conferința "The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova" Chișinău, Moldova, 28-30 mai 2014 | ||||||
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Pag. 129-129 | ||||||
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In the present work it is described a method of synthesis and properties of mixed-ligand copper(II) coordination compounds that contain streptocid, sulfacyl, sulfazine, etazole and 4methyl- or 4-ethylthiosemicarbazones of salicylaldehyde and 2-hydroxy-1-naphthaldehyde. It was found, that these compounds possess antimicrobial and antitumor activity. The synthesis of the target compounds was done according to the scheme . The composition and structure of the synthesized compounds were determined on the basis of data from elemental analysis, IR spectroscopy, and magnetochemical research. Synthesized coordination compounds I-XXII show selective antimicrobial activity towards a series of standard strains of Staphylococcus aureus (ATCC 25923), Enterococcus faecalis, Escherihia coli (ATCC 25922), Salmonella abony (GISK 03/03), and Candida albicans in the range of concentration 0.0015-0.25 mg/mL. It was found that composition, structure, bacteriostatic and bactericidal activity of these compounds depends on the nature of the alkyl moiety of the thiosemicarbazone. Moreover, the sinthisezed coordination compounds I-XXII inhibit the human promyelocytic leukemia HL-60 cells’ proliferation up to 100% in the range of concentration 10-5 -10-6 mol/l. |
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