Nowadays the searching for new biologically active substances in order to create new high-performance drugs is the main task of many synthetic organic groups. Econazole (4a) and miconazole (4b) are bio-active agents which damage fungal organisms by interfering with ergoesterol biosynthesis [1,2]. These compounds are usually applied in the treatment of vaginal diseases and several fungal infections of the skin of both human and animals, being well tolerated in clinical practice and showing biological activity shortly after application. In this communication we present elaboration and synthesis of econazole, miconazole and their nitrogen analogues using ionic liquids According to the presented scheme the first step involves the synthesis of ionic liquids from imidazole or 1,2,4-triazole and tert-butyl bromide [3]. The next one is the coupling with 2-halogen-1-(2,4-dichlorophenyl)ethanone, and finaly the processes of reduction and alkylation with corresponding benzyl chloride occurs in the presence of sodium hydride. The yield of products for each stage is no smaller than 75%. The author thanks the Moldavian State program project (14.518.04.08A) for financial support and Prof. Macaev F. and Dr. Stîngaci E. for helpful discussions.