Molecular diversity from nitrogen organic salts: preparation of novel scaffolds and focused targets
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2019-04-18 16:40
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CURLAT, Serghei; SUCMAN, Natalia; STINGACI, Eugenia; POGREBNOI, Serghei; BOLDESCU, Veaceslav; STEFANET, V.; VALICA, Vladimir; UNCU, Livia; KRAVTSOV, Viktor; BACA, Svetlana; MACAEV, Fliur. Molecular diversity from nitrogen organic salts: preparation of novel scaffolds and focused targets. In: Materials Science and Condensed Matter Physics. Ediția a 9-a, 25-28 septembrie 2018, Chișinău. Chișinău, Republica Moldova: Institutul de Fizică Aplicată, 2018, p. 94.
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Materials Science and Condensed Matter Physics
Ediția a 9-a, 2018
Conferința "International Conference on Materials Science and Condensed Matter Physics"
Chișinău, Moldova, 25-28 septembrie 2018

Molecular diversity from nitrogen organic salts: preparation of novel scaffolds and focused targets


Pag. 94-94

Curlat Serghei1, Sucman Natalia1, Stingaci Eugenia1, Pogrebnoi Serghei1, Boldescu Veaceslav1, Stefanet V.2, Valica Vladimir2, Uncu Livia2, Kravtsov Viktor3, Baca Svetlana3, Macaev Fliur12
 
1 Institute of Chemistry,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Institute of Applied Physics
 
Disponibil în IBN: 16 ianuarie 2019


Rezumat

The organic salts can be serving as versatile building blocks for the synthesis of a number of important and often novel biologically active compounds. Some examples for the strategic use of amines transformations that enable efficient, flexible and straightforward synthesis of structurally demanding cyclic products of magnetic and biological significance will be discussed. Particular focus will be on the application of quaternization of threesubstituted amines and N-substituted azoles for production of organic salts and formation of magnetic ionic liquids by a template directed process. The feasibility of use of organic salts in the development of new pharmaceutical entities will be presented in the frame of such advantageous properties as low costs, simplicity in preparation and purification, controllable permeability through biological barriers. Previously, for organic salts more or less selective cytotoxicity against different types of cancer cells has been demonstrated. However, only antiproliferative activity has been presented with only few studies that have gone further to explore the mechanisms of the apparent cytotoxicity.