Compounds with garnet structure well known as materials for luminescent applications in different fields of the human activity: HEP, medicine, solid-state lighting, homeland security and others. High flexibility of crystalline lattice to substitution makes possible the engineering new compounds with garnet structure. The two different approaches, homovalent and heterovalent substitution, may be used for this. Both of them leads to change of ―metal-oxygen‖ bond length and consequently influence on the luminescence properties of rare-earth ions due to distortion of their crystalline surrounding. At the heterovalent substitution unlike to the homovalent one, the charge balance should take into account. Thus, in accordance with the above, the development of new approaches and modification of existing ones to synthesis of compounds with garnet structure is actual.  The overview of the results of obtaining and investigation of the different compounds with garnet structure will present in the report. The possibility of obtaining complex non-stoichiometric compounds with garnet structure (YAG:Ce + oxide, where oxide is Y2O3, Lu2O3, HfO2 or La2O3 and LuAG:Ce + Lu2O3) will be shown [1]. The influence of their composition on structural and luminescent properties will be discussed. The results of obtaining and investigation the transparent ceramic based on them will be presented [2]. Furthermore, the possibility of obtaining heterovalently substituted garnets with using co-precipitation approach will be demonstrated [3]. The possibility of obtaining such compounds in glass-ceramic form by direct growth of their crystallites in the glass matrix will be shown and discussed. The possible mechanism of their growth will be proposed. The possibility of using garnet structure peculiarities for stabilization of the rare-earth ions in required valence state will be shown. The results of obtaining and investigation of glass ceramics based on the substituted Y3Al5O12:Eu2+,3+, Gd3Ga2Al3O12:Ce, Gd3Al2Ga3O12:Ce and Y3Al2B3O12:Ce garnets will be discussed too.