Синтез и антивирусная активность новых производных оксиндола
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2021-09-24 15:24
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547.756 (5)
Chimie organică (475)
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СУКМАН, Наталья. Синтез и антивирусная активность новых производных оксиндола. In: Ştiinţă, educaţie, cultură , 9 februarie 2018, Comrat. Comrat, Republica Moldova: Universitatea de Stat din Comrat, 2018, Vol.1, pp. 147-150. ISBN 978-9975-83-057-7.
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Ştiinţă, educaţie, cultură
Vol.1, 2018
Conferința "Ştiinţă, educaţie, cultură"
Comrat, Moldova, 9 februarie 2018

Синтез и антивирусная активность новых производных оксиндола

CZU: 547.756

Pag. 147-150

Сукман Наталья
 
Комратский государственный университет
 
Disponibil în IBN: 20 decembrie 2018


Rezumat

The synthesis and antiviral activity evaluation of new derivatives of oxindoles has been realized. The synthesized compounds exhibited different cytotoxicity. As far as the antiviral activity is concerned, none of the title compounds turned out active against Reo-1, Sb-1, VSV, RSV, YFV and VV viruses. The results obtained against Bovine Viral Diarrhoea Virus (BVDV) showed that three compounds (2j, 3a, 3e) resulted moderate active. Among all of them, the most potent compound was 2j, with EC50 of 6.6 μM.). It should be noticed that compound 3e showed moderate activity against HIV-1 (EC50 >16 – m >59μM).

Cuvinte-cheie
organic chemistry, organic synthesis, isatin, Thiosemicarbazones, cytotoxicity, antiviral activity,

oxindoles, spirooxindoles