Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves

Dinu Mihaela; Anghel Adriana-Iuliana; Olaru Octavian-Tudorel; Şeremet Oana Cristina; Calalb Tatiana; Cojocaru-Toma Maria; Negreş Simona; Hovaneţ Marilena Viorica; Zbârcea Cristina Elena; Ancuceanu Robert

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DINU, Mihaela, ANGHEL, Adriana-Iuliana, OLARU, Octavian-Tudorel, ŞEREMET, Oana Cristina, CALALB, Tatiana, COJOCARU-TOMA, Maria, NEGREŞ, Simona, HOVANEŢ, Marilena Viorica, ZBÂRCEA, Cristina Elena, ANCUCEANU, Robert. Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves. In: Farmacia, 2017, nr. 2(65), pp. 289-294. ISSN 0014-8237.

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Farmacia

Numărul 2(65) / 2017 / ISSN 0014-8237

Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves

Pag. 289-294

Dinu Mihaela¹, Anghel Adriana-Iuliana¹, Olaru Octavian-Tudorel¹, Şeremet Oana Cristina¹, Calalb Tatiana², Cojocaru-Toma Maria², Negreş Simona¹, Hovaneţ Marilena Viorica¹, Zbârcea Cristina Elena¹, Ancuceanu Robert¹

¹ University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy

Disponibil în IBN: 17 decembrie 2018

Rezumat

The dry hydro-ethanolic extract obtained from leaves of Amaranthus retroflexus L. (Amaranthaceae) with an yield of 22.53% was assessed with respect to its acute toxicity in NMRI mice, cytotoxicity on the crustacean Daphnia magna and phytotoxicity on Triticum aestivum L. The lack of lethality and of any change in the indicators followed in mice (2000 mg/kg b.w. po) was demonstrated, the extract being classified into the 5^th category of the Global Harmonized System (GHS). The Daphnia magna test results indicated a low toxicity (LC50 of 1053.0 µg/mL), in agreement with the results above, and the cytotoxicity and genotoxicity on plant cell, investigated by the Triticum bioassay manifest at high concentrations only (1.00% - 0.100%), for which changes in the mitotic film are also observed: mitoinhibition, anaphases with retarded chromosomes, metaphases with “sticky” chromosomes.

Cuvinte-cheie
Amaranthus, Citotoxicity, Daphnia magna, Phytotoxicity, Triticum test, genotoxicity

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