Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves
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DINU, Mihaela; ANGHEL, Adriana-Iuliana; OLARU, Octavian-Tudorel; ŞEREMET, Oana; CALALB, Tatiana; COJOCARU-TOMA, Maria; NEGREŞ, Simona; HOVANEŢ, Viorica; ZBÂRCEA, Cristina Elena; ANCUCEANU, Robert. Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves. In: Farmacia. 2017, nr. 2(65), pp. 289-294. ISSN 0014-8237.
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Numărul 2(65) / 2017 / ISSN 0014-8237

Toxicity investigation of an extract of Amaranthus Retroflexus L. (Amaranthaceae) leaves

Pag. 289-294

Dinu Mihaela1, Anghel Adriana-Iuliana1, Olaru Octavian-Tudorel1, Şeremet Oana1, Calalb Tatiana2, Cojocaru-Toma Maria2, Negreş Simona1, Hovaneţ Viorica1, Zbârcea Cristina Elena1, Ancuceanu Robert1
1 University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
Disponibil în IBN: 17 decembrie 2018


The dry hydro-ethanolic extract obtained from leaves of Amaranthus retroflexus L. (Amaranthaceae) with an yield of 22.53% was assessed with respect to its acute toxicity in NMRI mice, cytotoxicity on the crustacean Daphnia magna and phytotoxicity on Triticum aestivum L. The lack of lethality and of any change in the indicators followed in mice (2000 mg/kg b.w. po) was demonstrated, the extract being classified into the 5th category of the Global Harmonized System (GHS). The Daphnia magna test results indicated a low toxicity (LC50 of 1053.0 µg/mL), in agreement with the results above, and the cytotoxicity and genotoxicity on plant cell, investigated by the Triticum bioassay manifest at high concentrations only (1.00% - 0.100%), for which changes in the mitotic film are also observed: mitoinhibition, anaphases with retarded chromosomes, metaphases with “sticky” chromosomes.

Amaranthus, Citotoxicity, Daphnia magna, Phytotoxicity, Triticum test, genotoxicity