Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: A combined experimental and theoretical study
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CRIŞAN, Manuela E., HALIP, Liliana, BOUROSH, Pavlina, CHICU, Sergiu Adrian, CHUMAKOV, Yurii. Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: A combined experimental and theoretical study. In: Chemistry Central Journal, 2017, nr. 1(11), p. 0. ISSN 1752-153X. DOI: https://doi.org/10.1186/s13065-017-0346-5
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Chemistry Central Journal
Numărul 1(11) / 2017 / ISSN 1752-153X

Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: A combined experimental and theoretical study

DOI: https://doi.org/10.1186/s13065-017-0346-5

Pag. 0-0

Crişan Manuela E.1, Halip Liliana1, Bourosh Pavlina2, Chicu Sergiu Adrian3, Chumakov Yurii2
 
1 Institute of Chemistry Timisoara of the Romanian Academy,
2 Institute of Applied Physics, Academy of Sciences of Moldova,
3 Necunoscută, Germania
 
Disponibil în IBN: 15 decembrie 2018


Rezumat

Background: Nitroaromatic and chloronitroaromatic compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic acid are promising new agents for the treatment of main infectious killing diseases in the world: immunodeficiency diseases and tuberculosis. Results: New ethanolamine nitro/chloronitrobenzoates were synthesized and characterized by X-ray crystallography, UV–vis, FT-IR and elementary analysis techniques. The toxicity of the compounds prepared and correspondent components was evaluated using Hydractinia echinata as test system. A significant lower toxicity was observed for nitroderivative compared with chloronitro-derivatives and individual components. Crystallographic studies, together with the chemical reactivity and stability profiles resulted from density functional theory and ab initio molecular orbital calculations, explain the particular behavior of ethanolamine 4-nitrobenzoate in biological test. Conclusions: The experimental and theoretical data reveal the potential of these compounds to contribute to the design of new active pharmaceutical ingredients with lower toxicity.

Cuvinte-cheie
Chemical reactivity, Nitrobenzoic and chloronitrobenzoic acids and derivatives, Single crystal x-ray diffraction, toxicity