Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one

Pogrebnoi Serghei; Chiriţă Cornel; Valica Vladimir; Makaev Fliur; Chifiriuc Mariana-Carmen; Kamerzan Crina Maria; Uncu Livia; Uncu Andrei; Negreş Simona; Ionică Floriana Elvira; Nicolescu Florica; Marandiuc Ilinca Mihaela; Ştefănescu Emil

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Articolul urmator

1084

SM ISO690:2012

POGREBNOI, Serghei, CHIRIŢĂ, Cornel, VALICA, Vladimir, MAKAEV, Fliur, CHIFIRIUC, Mariana-Carmen, KAMERZAN, Crina Maria, UNCU, Livia, UNCU, Andrei, NEGREŞ, Simona, IONICĂ, Floriana Elvira, NICOLESCU, Florica, MARANDIUC, Ilinca Mihaela, ŞTEFĂNESCU, Emil. Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one. In: Farmacia, 2017, nr. 1(65), pp. 69-74. ISSN 0014-8237.

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Farmacia

Numărul 1(65) / 2017 / ISSN 0014-8237

Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one

Pag. 69-74

Pogrebnoi Serghei¹, Chiriţă Cornel², Valica Vladimir³, Makaev Fliur¹, Chifiriuc Mariana-Carmen⁴, Kamerzan Crina Maria⁴, Uncu Livia³, Uncu Andrei³, Negreş Simona², Ionică Floriana Elvira⁵, Nicolescu Florica², Marandiuc Ilinca Mihaela⁶, Ştefănescu Emil²

¹ Institute of Chemistry of the Academy of Sciences of Moldova,
² University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
³ ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
⁴ University of Bucharest,
⁵ University of Medicine and Pharmacy Craiova,
⁶ Bioplus Pharmacy

Disponibil în IBN: 14 decembrie 2018

Rezumat

The aim of the current study was the antimicrobial screening of a newly synthesised thiadiazolic compound, 2-(propylthio)-5H-[1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. The study was conducted for the qualitative and quantitative assessment of the antimicrobial activity, as well as its influence on the adherence capacity inhibition of certain microbial strains. Antimicrobial activity has been approached by means of instrumental techniques, such as flow cytometry. The results of this study have demonstrated the effect of the newly synthesised compound against Gram-negative bacteria through the permeabilization of the bacterial cell wall and against Gram-positive bacteria through the inhibition of the efflux pumps activity.

Cuvinte-cheie
Antimicrobial action, Flow cytometry, Thiadiazoles, tuberculosis

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