Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
374 0
SM ISO690:2012
POGREBNOI, Serghei; CHIRIŢĂ, Cornel; VALICA, Vladimir; MACAEV, Fliur; CHIFIRIUC, Mariana-Carmen; KAMERZAN, Crina Maria; UNCU, Livia; UNCU, Andrei; NEGREŞ, Simona; IONICĂ, Floriana Elvira; NICOLESCU, Florica; MARANDIUC, Ilinca Mihaela; ŞTEFĂNESCU, Emil. Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one. In: Farmacia. 2017, nr. 1(65), pp. 69-74. ISSN 0014-8237.
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Farmacia
Numărul 1(65) / 2017 / ISSN 0014-8237

Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one


Pag. 69-74

Pogrebnoi Serghei1, Chiriţă Cornel2, Valica Vladimir3, Macaev Fliur1, Chifiriuc Mariana-Carmen4, Kamerzan Crina Maria4, Uncu Livia3, Uncu Andrei3, Negreş Simona2, Ionică Floriana Elvira5, Nicolescu Florica2, Marandiuc Ilinca Mihaela6, Ştefănescu Emil2
 
1 Institute of Chemistry of the Academy of Sciences of Moldova,
2 University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
4 University of Bucharest,
5 University of Medicine and Pharmacy Craiova,
6 Bioplus Pharmacy
 
Disponibil în IBN: 14 decembrie 2018


Rezumat

The aim of the current study was the antimicrobial screening of a newly synthesised thiadiazolic compound, 2-(propylthio)-5H-[1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. The study was conducted for the qualitative and quantitative assessment of the antimicrobial activity, as well as its influence on the adherence capacity inhibition of certain microbial strains. Antimicrobial activity has been approached by means of instrumental techniques, such as flow cytometry. The results of this study have demonstrated the effect of the newly synthesised compound against Gram-negative bacteria through the permeabilization of the bacterial cell wall and against Gram-positive bacteria through the inhibition of the efflux pumps activity.

Cuvinte-cheie
Antimicrobial action, Flow cytometry, Thiadiazoles, tuberculosis