|Conţinutul numărului revistei|
| SM ISO690:2012|
POGREBNOI, Serghei; CHIRIŢĂ, Cornel; VALICA, Vladimir; MACAEV, Fliur; CHIFIRIUC, Mariana-Carmen; KAMERZAN, Crina Maria; UNCU, Livia; UNCU, Andrei; NEGREŞ, Simona; IONICĂ, Floriana Elvira; NICOLESCU, Florica; MARANDIUC, Ilinca Mihaela; ŞTEFĂNESCU, Emil. Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(Propyl-thio)-5H-[1,3,4]-thiadiazole[2,3-B]-quinazoline-5-one. In: Farmacia. 2017, nr. 1(65), pp. 69-74. ISSN 0014-8237.
|Numărul 1(65) / 2017 / ISSN 0014-8237|
The aim of the current study was the antimicrobial screening of a newly synthesised thiadiazolic compound, 2-(propylthio)-5H-[1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. The study was conducted for the qualitative and quantitative assessment of the antimicrobial activity, as well as its influence on the adherence capacity inhibition of certain microbial strains. Antimicrobial activity has been approached by means of instrumental techniques, such as flow cytometry. The results of this study have demonstrated the effect of the newly synthesised compound against Gram-negative bacteria through the permeabilization of the bacterial cell wall and against Gram-positive bacteria through the inhibition of the efflux pumps activity.
Antimicrobial action, Flow cytometry, Thiadiazoles, tuberculosis