A CPAnet consensus statement on research priorities for chronic pulmonary aspergillosis: A neglected fungal infection that requires attention
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GODET, Cendrine; ALASTRUEY-IZQUIERDO, Ana; FLICK, Holger; HENNEQUIN, Christophe; MIKILPS-MIKGELBS, Rihards; MUNTEANU, Oxana; PAGE, Iain D.; SEIDEL, Danila; SALZER, Helmut J.F.. A CPAnet consensus statement on research priorities for chronic pulmonary aspergillosis: A neglected fungal infection that requires attention. In: Journal of Antimicrobial Chemotherapy. 2018, nr. 2(73), pp. 280-286. ISSN 0305-7453.
10.1093/jac/dkx390
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Journal of Antimicrobial Chemotherapy
Numărul 2(73) / 2018 / ISSN 0305-7453

A CPAnet consensus statement on research priorities for chronic pulmonary aspergillosis: A neglected fungal infection that requires attention


DOI: 10.1093/jac/dkx390
Pag. 280-286

Godet Cendrine1, Alastruey-Izquierdo Ana2, Flick Holger3, Hennequin Christophe456, Mikilps-Mikgelbs Rihards7, Munteanu Oxana8, Page Iain D.910, Seidel Danila11, Salzer Helmut J.F.12
 
1 Centre Hospitalier Universitaire de Poitiers, Service de maladies infectieuses et tropicales,
2 Instituto de Salud Carlos III,
3 Medical University of Graz,
4 Sorbonne Universités, UPMC Université Paris,
5 Centre d'Immunologie et des Maladies Infectieuses,
6 Hôpital Saint-Antoine, Service de Parasitologie,
7 Riga East University Hospital,
8 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
9 University Hospital of South Manchester,
10 The University of Manchester,
11 University Hospital Cologne,
12 Research Center Borstel
 
Disponibil în IBN: 12 decembrie 2018


Rezumat

Chronic pulmonary aspergillosis (CPA) is a severe fungal infectionwith a highmorbidity andmortality, and is usually seen in immunocompetent patients with respiratory disorders. Clinical presentation is nonspecific and often overlaps with the symptoms and the radiological pattern caused by the underlying disease. Clinical management of CPA is further hampered by limited information about the epidemiology, disease dynamics, sensitivity and specificity of different mycological tests, mechanisms of antifungal resistance, efficient treatment and management strategies. In order to contribute to a better understanding and to improve CPA patient management and outcome, we established the Chronic Pulmonary Aspergillosis Network (CPAnet), a self-organized multinational research collaboration. Key research priorities, defined by using a modified Delphi process, include the establishment of a multinational web-based registry, the validation of different diagnostic tests, the establishment of a culture collection from samples of patientswith proven CPA and the establishment of a consensus on a treatment outcome definition.

Cuvinte-cheie
article, chronic disease, consensus, Delphi study, lung aspergillosis, neglected disease, nonhuman, research priority, treatment outcome, human