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SM ISO690:2012 KOENSGEN, Dominique, STOPE, Matthias, TUERBACHOVA, Ivana, BRUENNERT, Daniela, KOHLMANN, Thomas, BRAICU, Ioana, SEHOULI, Jalid, DENKERT, Carsten, DARB-ESFAHANI, Silvia, STICKELER, Elmar, SOFRONI, Dumitru, DAHL, Edgar, MUSTEA, Alexander. Expression, intracellular localization, and prognostic value of plasminogen activator inhibitor 1 and PAI-1 RNA-Binding Protein 1 in primary and recurrent ovarian cancer: A study of the tumor bank ovarian cancer network. In: Gynecologic and Obstetric Investigation, 2018, nr. 5(83), pp. 508-514. ISSN 0378-7346. DOI: https://doi.org/10.1159/000479027 |
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Gynecologic and Obstetric Investigation | |
Numărul 5(83) / 2018 / ISSN 0378-7346 | |
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DOI:https://doi.org/10.1159/000479027 | |
Pag. 508-514 | |
Rezumat | |
Background: The plasminogen activator system plays a key role in ovarian cancer (OC) tumor progression. The plasminogen activator inhibitor type 1 (PAI-1) and the recently identified PAI-1 RNA binding protein 1 (PAI-RBP1) are primary regulators of plasminogen activation and thus are putative biomarkers for OC progression. Methods: One hundred fifty six OC patients were analyzed to identify the presence of PAI-1 and PAI-RBP1 and subsequently correlated to clinicopathological parameters. Primary cells obtained from OC patient samples were applied in fluorescence microscopy analysis for examination of PAI-1 and PAI-RBP1 distribution. Results: PAI-1 and PAI-RBP1 have been found to be predictive markers for OC patients' outcome. PAI-1 levels significantly correlated with volume of ascites, FIGO staging, and lymph node status. PAI-RBP1 expression significantly correlated with age at first diagnosis, histological tumor type, presence of distant metastasis (pM), and recurrence. PAI-1 showed a trend toward association and PAI-RBP1 was significantly associated with progression-free survival. Notably, PAI-1 protein in recurrent OC tissues was exclusively localized in the nucleus. Conclusion: This study has shown that a combination of PAI-1 and PAI-RBP1 may represent novel prognostic factor for OC. Prospective trials are needed. |
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Cuvinte-cheie gene expression, Intracellular localization, I-1, N, A-binding protein 1, Plasminogen activator inhibitor 1, ovarian cancer, P, R, A |
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